1. The effects of corticosteroid pretreatment on acetylcholine (ACH)-induced contraction of bronchial smooth muscle (BSM) were studied. 2. ACH dose-response curves for dexamethasone (DM)- and corticosterone (B)-treated but not deoxycorticosterone (DOC)-treated BSM were significantly shifted to the right; this provides evidence that glucocorticoid treatment reduced the sensitivity of BSM to ACH. 3. Morphine enhanced BSM contraction in response to ACH by 20%. DM suppressed this enhancement. 4. These findings correlated well with the reduction of muscarinic receptor numbers in BSM by glucocorticoids in our previous study. In addition, glucocorticoids reduced the sensitivity of BSM to opioids.
1. Male Sprague-Dawley rats were made either hyper- or hypothyroid with thyroxine or 4-methyl-2-thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3',5'-monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper- and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.
Abstract:Background: Anatomical structures of head are essential to carry out almost all of dental procedures.In this regard to study the variation of mental and mandibular foramens are prerequisite for the intervention of clinical dentistry. The study was undertaken to determine the anatomical position of the mental foramen (mF) and mandibular foramen (MF) and their relationship. Methods and Methods: Eighty-seven selected Malay patients were examined at Universiti Kebangsaan Malaysia Dental Clinics in which 34 were male and 53 were female. The size and position of the mF in relation to tooth position were recorded. The size and position of the MF were recorded based on the horizontal and vertical dimensions consisting of reference point's namely anterior and posterior border of ascending border of ramus as well as mandibular notch and lower border of mandibular ramus, respectively. Results: The mF was found to be most in line with second premolar (49%) on both sides in both sexes. The size of mF was larger on the right side and in male (p<0.05). The size of MF on the right and left side for both male and female did not differ significantly (p>0.05). The mean distance between the MF to occlusal plane was 10mm (SD ±1.56) for both sides. There was no significant difference between mF and MF position (p>0.05). Conclusion: In the Malay population, anatomical relationship and variation between mental and mandibular foramen were not found to be significant. The information would be useful in dental intervention of the clinicians.
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