Burkitt lymphoma is one type of non-Hodgkin lymphomas that is highly malignant and dificult to cure. Atypical Burkitt lymphoma, one subtype of this tumor according to the WHO classification, is a rare disease. We describe the case of a 78-year-old man who was given a diagnosis of atypical Burkitt lymphoma. Paresthesia of the right mental region arose 4 days before presentation. Three mass lesions (in the right pterygomandibular space, the left mandibular ramus, and the duodenum) were found on clinical and radiologic examinations. Histopathologically, a sheet of predominantly medium-sized proliferating lymphoid cells with nuclear pleomorphism, a starrysky pattern, and a very high growth fraction were revealed. We therefore diagnosed atypical Burkitt lymphoma. The disease was Stage IV according to the Ann Arbor classification. He was transferred to a hematology unit and received COP therapy. Although transient improvement was noted, the patient soon showed signs of central nervous system involvement and died 2 months later.
We report a case of holoprosencephaly with cleft lip and palate. The patient was a 26-year-old woman who presented with malocclusion and masticatory dysfunction. She had undergone cleft surgery, including lip and palatoplasty, and alveolar bone grafting until 18 years of age, but her occlusion was not effectively managed.Facial anomalies included slight orbital hypotelorism and trigonocephaly, severe mid-facial delayedgrowth with a flat nose and a scar from bilateral chiloplasty. Intraoral examination showed malocclusion, cross bite, a severely contracted dental arch, and multiple tooth defects of the maxilla.We successfully treated her malocclusion by the following procedures: (1) alveolar bone graft for implants,(2) orthodontic treatment of the mandible and dental treatment of the upper and lower teeth,(3)sagital splitting ramus osteotomy (SSRO),(4)application of dental implants and vestibular extension with a skin graft, and prosthetic treatment of the maxilla.
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