A 9-month old male Boerboel was presented at the University of Abuja Small Animal Clinic with a primary complaint of inappetence and micturition with brownish-yellow urine. Physical examination revealed pale mucous membranes, enlarged pre-scapular lymph nodes, bilateral ocular discharges, pyrexia (41.2 °C), depression and the presence of ticks of the genus Rhipicephalus sanguineus on the body of the animal. History revealed that the dog was recently vaccinated against canine distemper, hepatitis, leptospirosis, parainfluenza, parvovirus (DHLPP) and rabies six days prior to the onset of clinical signs, and had been anorexic. Following clinical examination, blood and faecal samples were collected for biochemical and parasitological analyses, and the results revealed the presence of intraerythrocytic Babesia parasites, normocytic and normochromic anaemia with extensive cellular damage. However, during the course of the investigation, the dog died. With appropriate consent, a post-mortem examination was carried out. Diffuse oedema with interstitial pneumonia in the lung, focal haemorrhage with cellular infiltration in the heart and progressive necrosis of epithelial cells within the seminiferous tubules of the testicles were observed. Many of the observed clinicopathological alterations were consistent with complicated babesiosis. However, in the current case, some unique systemic complications such as testicular degeneration, which has not been previously observed in the Boerboel are discussed.