Highlights Prevalence of pulmonary thromboembolic disease (PTE) is 38% in COVID-19 patients who underwent CTPA. Patients with more severe COVID-19 changes are more likely to have PTE. Majority of PTE is observed within smaller pulmonary vessels (75%) and lungs demonstrating COVID-19 changes (72%). Subsegmental vessels should be scrutinized for presence of PTE. D-dimer values may have potential in guiding anticoagulation therapy and evaluating prognosis in these patients.

The study highlighted the need to include a whole-level approach in organisation to improve research culture and to include communication within the Cooke's framework if evidence-based practice is to influence the quality of patient care.

Perampanel was fairly effective in a heterogeneous group of 96 children and adolescents with very refractory epilepsy. The rate of adverse events leading to discontinuation was considerable in this group.

Paediatric obstructive sleep apnoea (OSA) is characterised by stertor, intermittent oxygen desaturation and repeated nocturnal awakening. 1 If left untreated, it can have significant repercussions, such as cor pulmonale, growth and developmental delay. 2 Adenotonsillectomy has proven to be effective in improving OSA outcomes in the majority of children. 3 Tonsillectomy (with or without adenoidectomy) is the most frequent ENT procedure comprising of 17% of the workload in the UK. 4 There has been an effort in recent years to improve day case surgery rates for these patients and to ensure safe delivery of services at secondary and tertiary centres within the UK for children with OSA. 5 Improvements in patient care will therefore have a widereaching impact on children and their families. Knowledge of post-operative complication rates for childrenwith OSA undergoing adenotonsillectomy is essential to be able to deliver safe and appropriate care and to support informed consent and shared decision-making. Age and comorbidities have been investigated to varying degrees to determine whether day case surgery and surgical delivery in secondary care centres are safe. [6][7][8] Since 2015, our paediatric tertiary centre has undergone a 3-stage service improvement process aimed at improving the safety of day case adenotonsillectomy for paediatric patients with OSA. We present our data and outcomes from our tertiary centre experience which has been used to help create the national strategy, released in 2019, for managing paediatric patients with OSA undergoing adenotonsillectomy.

In this pilot study, a streamlined, dedicated, virtual service for rapid assessment (within 2 weeks of referral) of choroidal naevomelanocytic lesions was shown to be feasible and safe. Such a model of service delivery may prove cost-efficient while optimising patient experience. Further prospective studies are required for formal validation of the proposed service model.

Early CW effectively and safely improves growth up to 2 years after transplantation, particularly in prepubertal children.

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PurposeThis is a feasibility study assessing use of a mobile phone application (app.) to measure nutrient intake relevant to age-related macular degeneration (AMD).MethodsInclusion criteria were age over 40 and ownership of a smartphone. Participants included healthy volunteers and those with ophthalmic conditions. They were asked to record daily food intake for a minimum of 3 days in a paper food diary and the app. A dietician analyzed the food diaries, and an independent researcher analyzed data from the app. Average daily intake of nutrients relevant to AMD (docosahexaenoic acid [DHA], eicosapentaenoic acid [EPA], vitamins E and C, copper, zinc, and lutein + zeaxanthin) were calculated for both and then compared.ResultsA total of 54 participants completed the app. and food diary. Male-to-female ratio was 7:20. Median (interquartile range [IQR]) age was 57 years (45.3–68.7 years). More than 90% of all values were within the limits of agreement for all micronutrients. Bland Altman agreement plots demonstrated clinically acceptable agreement between the two systems of analysis.ConclusionsThis study has demonstrated that the app. is a feasible alternative to the food diary for assessing nutrient intake relevant to AMD. Further studies are suggested to assess long-term adherence and effect of the app. on nutrient intake in AMD patients.Translational RelevanceAfter smoking, nutritional modification is the key modifiable factor to reduce incidence of AMD. Use of the app. could be an efficient, easy way to monitor and improve dietary intake of required nutrients pertinent to AMD.