How the brain preserves information about multiple simultaneous items is poorly understood. We report that single neurons can represent multiple stimuli by interleaving signals across time. We record single units in an auditory region, the inferior colliculus, while monkeys localize 1 or 2 simultaneous sounds. During dual-sound trials, we find that some neurons fluctuate between firing rates observed for each single sound, either on a whole-trial or on a sub-trial timescale. These fluctuations are correlated in pairs of neurons, can be predicted by the state of local field potentials prior to sound onset, and, in one monkey, can predict which sound will be reported first. We find corroborating evidence of fluctuating activity patterns in a separate dataset involving responses of inferotemporal cortex neurons to multiple visual stimuli. Alternation between activity patterns corresponding to each of multiple items may therefore be a general strategy to enhance the brain processing capacity, potentially linking such disparate phenomena as variable neural firing, neural oscillations, and limits in attentional/memory capacity.

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In the era of big data, it is necessary to split extremely large data sets across multiple computing nodes and construct estimators using the distributed data. When designing distributed estimators, it is desirable to minimize the amount of communication across the network because transmission between computers is slow in comparison to computations in a single computer. Our work provides a general framework for understanding the behavior of distributed estimation under communication constraints for nonparametric problems. We provide results for a broad class of models, moving beyond the Gaussian framework that dominates the literature. As concrete examples we derive minimax lower and matching upper bounds in the distributed regression, density estimation, classification, Poisson regression and volatility estimation models under communication constraints. To assist with this, we provide sufficient conditions that can be easily verified in all of our examples.

ABSTRACT:74 How the brain preserves information about multiple simultaneous items is poorly 75 understood. Here, we provide evidence that the brain may accomplish this using time division 76 multiplexing, or interleaving of different signals across time, to represent multiple items in a 77 single neural channel. We evaluated single unit activity in an auditory coding "bottleneck", the 78 inferior colliculus, while monkeys reported the location(s) of one or two simultaneous sounds.