Deep learning models applied to healthcare applications including digital pathology have been increasing their scope and importance in recent years. Many of these models have been trained on The Cancer Genome Atlas (TCGA) atlas of digital images, or use it as a validation source. This study shows that there are tissue source site (tss) specific patterns of TCGA images that could be used to identify contributing institutions without any explicit training. Furthermore, it was observed that a model trained for cancer subtype classification has discovered such tss specific patterns within digital slides to classify cancer types. Digital scanner configuration and noise, tissue stain variation and artifacts, and source site patient demographics are among factors that likely account for the observed bias. Therefore, researchers should be cautious of such bias when using histopathology datasets for developing and training deep networks.
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