-Effects of dose and duration of phenobarbital (PB) administration and those of co-admin---content and CYP2B expression, prolongation of coagulation time (activated partial thromboplastin time (APTT) and Thrombotest ® (TBT)) and an increase in anti-thrombin III (AT III) concentration in a dosedependent increases in hepatic cytochrome P450 content and CYP2B (CYP2B1 and CYP2B2) expression. APTT was prolonged from day 1 and AT III concentration was increased from day 2, whereas the day) was shortened after vitamin K 2
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