Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne disease in Africa, Asia, the Balkan peninsula, the southeast of Europe and the Middle East, with mortality rates of 3-30%. Transmission can also occur through contact with infected animals or humans. Aim: This observational, prospective case series aimed to investigate detectable viral genomic RNA in whole-body fluids and antibody dynamics in consecutive daily samples of patients diagnosed with CCHF until discharge from hospital. Methods: We tested 18 patients and 824 swabs and sera with RT-PCR and 125 serum samples serologically. Results: The longest duration until clearance of viral RNA was 18 days from serum collection and 18, 15, 13, 19 and 17 days, respectively, from nasal, oral, genital (urethral or vaginal) and faecal swab, and urine. In seven patients, viral load decreased in serum at the same time as it increased in urine or persisted at the same logarithmic values. Despite clearance in serum, viral RNA was detected in faeces and genital swabs in two and three patients, respectively. Viral clearance from body fluids occurred earlier than from serum in eight patients on ribavirin treatment. The shortest seroconversion time was 3 days after symptom onset for IgM and IgG. Seroconversion of IgG occurred until Day 14 of symptoms. Conclusion: We report persistence of viral RNA in urine, faeces and genital swabs despite serum clearance. This may indicate a need for extending isolation precautions, re-evaluating discharge criteria and transmission risk after discharge, and considering oral swabs as a less invasive diagnostic alternative.
Leptospirosis can present with severe cases such as polymyositis, peripheral neuropathy, and rarely, Guillain-Barré Syndrome (GBS). This paper reports a case who presented with dysarthria and GBS. A female patient presented with complaints of weakness, dizziness, diarrhea, and dysarthric. Her assessments included muscle strength globally 4/5 and deep tendon reflexes as hypoactive. An electromyographic examination was performed with the increase of weakness in the lower extremities, which indicated findings compatible with GBS. Antibodies against Leptospira biflexa serovar Patoc 1 at 1/400 titer were detected in the microscopic agglutination test (MAT). Neurological involvement in leptospirosis cases can range from meningoencephalitis to GBS. Keywords: dysarthria, Guillain-Barré syndrome, leptospirosis, acute kidney failure
Amaç: Bu çalışmanın amacı, ankilozan spondilit tanılı sülfasalazin ve biyolojik ilaç kullanan hastalarda SARS CoV-2 faktörünün neden olduğu akciğer tutulumunu incelemek. Gereç ve Yöntem: COVID-19 geçirmiş RT-PCR pozitif AS tanısı olan ve en az bir yıldır hastanemizde takibi olan hastaların dosya sistemleri retrospektif olarak gözden geçirildi. AS tanısı alan hastalar sülfasalazin ve biyolojik ajan kullananlar olarak iki gruba ayrıldı. Hastaların toraks bilgisayarlı tomografi (BT) sonuçları hafif, orta, şiddetli, iki taraflı ve tek taraflı olarak ayrıldı. Veriler ayrıca hasta ve kontrol grupları arasında karşılaştırıldı. Bulgular: Çalışmaya alınan 58 hastanın 26’sı biyolojik ajan, 32’si sülfasalazin alıyordu. DMARD kullanan hastalardan 17’si adalimumab, 4’ü etanercept, 2’si golimumab, 2’si sertolizumab ve 1’i infliximab kullanıyordu. AS grubundaki 13 hastada toraks bilgisayarlı tomografisinde SARS CoV-2 nedeniyle akciğer tutulumu vardı. 9’u erkek, 4’ü kadın olan hastaların COVID-19 nedeniyle hastaneye yatırıldığı görüldü. 10 hastada her iki akciğerde de COVID-19’a bağlı tutulum saptandı. Sonuç: otoimmün ve inflamatuar romatizmal hastalıklarda kullanılan immünomodülatör tedavilerin COVID-19 seyrini olumlu ya da olumsuz etkileyeceği henüz bilinmemektedir. Bizim çalışmamızda sulfasalazin ve biyolojik ajan kullanan AS tanılı hastalarda COVID-19 hafif semptomlarla seyretmiştir.
Although brucellosis is very common in the world and Türkiye, there are no evidence-based guidelines to guide the diagnosis and treatment of the disease. This guide has been prepared by the Turkish Society of Clinical Microbiology and Infectious Diseases to provide evidence-based recommendations to physicians from different specialties interested in the diagnosis and treatment of brucellosis. The recommendations of the Clinical Practice Guide Development Guide of the Infectious Diseases Society of America (IDSA) were taken as the basis for preparing this guide. The guideline preparation group determined 20 questions considered to be important in the diagnosis and treatment of brucellosis, and the publications that could answer these questions prepared in PICO (Population/Patient [P], Intervention [I], Comparison [C], Outcome [O]) format, were searched in ULAKBİM Tr Dizin, PubMed, Cochrane databases without date restrictions. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Working Group method was used to rank the evidence and determine the strength of the recommendations for each PICO question and for each individual outcome. Meta-analyses of comparative clinical studies were performed to answer the PICO questions. Individual participant data (IPD) meta-analyses with data obtained from case reports and case series were conducted in the absence of comparative clinical studies. It is planned to update the recommendations at regular intervals in line with the results of new studies.
Objective: While the coronavirus disease 2019 (COVID-19) pandemic was continuing at full speed, patients with Crimean-Congo hemorrhagic fever (CCHF), which is endemic in our region, apply to the emergency department simultaneously. The presence of computed tomography (CT) lesions suggesting COVID-19 in some CCHF patients has brought to our mind the question of whether there is CCHF lung involvement even though respiratory symptoms are not at the forefront. Methods:In this study, the findings of chest CT, demographic data and clinical symptoms of cases who had thorax tomography scan with suspicion of COVID-19 in the emergency department in the spring and summer of 2020 and were diagnosed with CCHF as a result of the evaluation and followed up in our clinic were compared with the findings of COVID-19 cases that were hospitalized and treated in the same period.Results: Seventy-seven COVID-19 and 25 CCHF cases were included in the study. Myalgia, headache, diarrhea, nausea and vomiting were significantly higher in CCHF patients (p <0.05). Cough was significantly more common in COVID-19 patients (p= 0.034). Groundglass opacity (GGO) was the most common tomography finding in CCHF, and cases without lung involvement were significantly higher (p = 0.001). GGO, consolidation, vascularization, atelectasis band, reverse halo, air-bubble, nodule were significantly high in COVID-19 patients. Conclusion:During the epidemic period, no pathological finding was found in thoracic CT in most of the CCHF cases, and the presence of involvement in the lung tomography in cases with similar clinical and laboratory findings should primarily suggest the diagnosis of COVID-19.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.