Background: The aim of this study was to ascertain whether oxidative stress is a causative factor of migraine attacks for Helicobacter pylori‐infected migraineurs.
Materials and Methods: A total of 35 consecutive migraine patients without aura who came to gastroenterology polyclinic with various complaints and diagnosed H. pylori infection were included in the study group and compared with a group of 29 patients (control group) without migraine and H. infection. H. pylori infection was diagnosed by histopathological biopsies, which were taken by endoscopy (Olympus‐GIFXQ240 endoscope). Both the diagnosis and the classification of migraine were made according to the International Headache Society criteria.
Blood samples for nitric oxide were taken from patients with migraine during headache‐free period as well as the control group.
The interaction of nitric oxide was measured by the determination of both nitrite and nitrate concentrations in the sample.
Results: The study group included 31 women and 4 men (mean age 49 ± 8 years) and the control group included 25 women and 4 men (mean age 52.6 ± 11 years). The mean frequency of migraine attacks was 2.94 ± 1.58 days/month and the mean duration of attacks was 21.2 ± 3 hours.
It was found that the study group has lower nitrate levels than the control group.
Conclusions: Our results do not support the role of oxidative stress in patients suffering from H. pylori infection and migraine.
Lichen planus (LP) is a T-cell-mediated disorder that may involve the skin, nails and mucosal surfaces. Conjunctival, laryngeal and oesophageal involvement were reported to be extremely rare manifestations of the disease. In this report, we present an oral LP case who complained of severe burning pain on his tongue and oral mucosa caused by ulcerative lesions and associated with conjunctival, laryngeal and oesophageal involvement. In addition, neurological examination revealed facial and abducens nerve palsy. To the best of our knowledge, we are presenting the first case of erosive oral LP associated with facial and abducens nerve paralysis. Although this association may be coincidental, according to an immunological concept proposed to explain the pathogenesis of Bell's palsy, degranulation of mast cells activated by complement or specific allergens with the release of histamine and other substances were to be presented responsible from nerve oedema, ischaemia and paralysis. As mast cell mediators are likely to be involved in the immunopathogenesis of OLP, we think that the cause of facial and bilateral abducens nerve palsy could be explained by the same mechanism. This case is a good example of the need for team work in lichen planus patients undergoing interdisciplinary consultations.
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