Introduction:
F18 and Ga68 radioisotopes are used in PET imaging for prostate cancer. It was aimed to calculate the prostate, testicle and bladder effective doses (ED) caused by F18 and Ga68 used in prostate cancer imaging with PET/CT via simulation with the GATE toolkit and evaluate the ED in terms of fertility.
Methods:
The prostate, testicle and bladder were defined together with their geometric properties and densities in GATE simulation. F18 and Ga68 with activity of 277.5 MBq and 151.7 MBq were identified in the prostate as a source organ. The ED, uncertainties, and S values were taken as an output file in the TXT format with the DoseActors command. S values were used for validation of the simulation.
Results:
The ED of the prostate, total testicle and bladder for F18 were found to be 6.627E-041.799E-06, 12.74E-074.11E-08 and 1.617E-054.317E-09 (Gy/s), respectively. The ED of the prostate, total testicle, and bladder for Ga68 were found to be 9.195E-042.660E-06, 6.54E-072.93E-08 and 4.290E-056.936E-09 (Gy/s), respectively.
Conclusions:
It was found that Ga68 produced high prostate and bladder ED, and F18 produced high testicular ED. In terms of male fertility, Ga68 seems to be a good alternative because it produces low testicular doses. The ED of the testicle both F18 and Ga68 were below the reported spermatogonia and azoospermia dose.
Background:
It is estimated that more than 1 million people are diagnosed with liver malignancy each year
and one of the treatments is radioembolization with Y-90 and Ho-166.
Objective:
The aim of this study is to calculate the absorbed doses caused by Y-90 and Ho-166 in tumor and liver
parenchyma using a phantom via Monte Carlo method.
Methods:
A liver model phantom including a tumor imitation of sphere (r =1.5cm) was defined in GATE. The total
activity of 40 mCi Y-90 and Ho-166 was prescribed into tumor imitation as source and 2x2x2 mm3 voxel-sized Dose-
Actors were identified at 30 locations. The simulation, performed to calculate the absorbed doses left by particles during
1 second for Y-90 and Ho-166, was run for a total of 10 days and 11 days, respectively. Total doses were calculated
by taking the doses occurring in 1 second as a reference.
Results:
The maximum absorbed doses were found to be 2.334E+03±1.576E+01 Gy for Y-90 and 7.006E+02±6.013E-
01 Gy for Ho-166 at the center of tumor imitation. The minimum absorbed doses were found to be 2.133E-03±1.883E-
01 Gy for Y-90 and 1.152E-02±1.036E-03 Gy for Ho-166 at the farthest location from source. The mean absorbed
doses in tumor imitation were found to be 1.50E+03±1.36E+00 Gy and 4.58E+02±4.75E-01 Gy for Y-90 and Ho-166,
respectively. And, the mean absorbed doses in normal parenchymal tissue were found to be2.07E+01±9.58E-02 Gy
and 3.79E+00±2.63E-02 Gy for Y-90 and Ho-166, respectively.
Conclusion:
Based on the results, Ho-166 is a good alternative to Y-90 according to dosimetric evaluation.
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