Methylcellulose may have antihealing properties that serve to decrease IOP in trabeculectomy. Although more work is needed in humans, because human tissue may be different in its response to the same procedure, the use of methylcellulose could be very promising.

Pigment epithelial detachment (PED) is a common entity in age-related macular degeneration and central serous chorioretinopathy. Nevertheless, it can manifest rarely without an obvious causative factor. The authors report 3 cases of PED that were atypical in terms of pattern and age presentation. The second case is associated with sickle cell disease, which has not been reported in literature as far and that could add to our knowledge of this disease entity. Methods: The three cases underwent ophthalmological examination, optical coherence tomography, fundus autoflourescence, fundus fluorescein angiography, full-field electroretinogram and visual evoked potential. Full medical evaluation was done. Results: Bilateral ocular fundus examination showed multiple, rounded lesions scattered all over the fundus in three cases and peripheral retinal pigment epithelial pigmentary changes in the periphery in two cases. Medical evaluation showed one case of sickle cell disease. Conclusion: The number of reports on atypical pigment epithelial detachment and their correlation is limited. In addition its occurrence with sickle cell disease in the second case is a novel correlation which has to be reported and followed-up.

Photocoagulation is routinely used as a major treatment method for many retinal disorders. The present study was conducted to investigate the protective effect of Grape seed extract (GSE) on reactive oxygen species produced during argon laser photocoagulation and also to explore the benefit of retinal photocoagulation over two session's argon laser compared to single session. Forty two pigmented rabbits weighted 2-2.5 Kg were used in this study. The animals were classified into three groups. The left eye for each animal was photocoagulated with 200 mW, 400 mW and 400 mw fractionated dose (FD) argon laser with and without GSE supplementation respectively. After 24 hours the retina was separated carefully, malondialdehyde level (MDA), total antioxidant capacity (TAC) and Fourier transform infrared spectroscopy (FT-IR) for retinal tissue were detected. FT-IR findings showed a positive result for GSE supplementation in reducing laser effects on the retinal tissue. Also, GSE supplementation improved the level of TAC in rabbit's retina exposed to argon laser with a concurrent decrease in MDA level. In conclusion, GSE has an extremely beneficial role in overcoming the resultant adverse biological effects of argon laser photocoagulation on retinal tissues due to its potent antioxidant properties. Results also revealed that retinal photocoagulation over two sessions was more protective for retinal tissue than single session argon laser.