The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To further elucidate the effect of CLU on tau pathology, we utilized a gene delivery approach in CLU knock-out (CLU KO) mice to drive expression of tau bearing the P301L mutation. We found that loss of CLU was associated with exacerbated tau pathology and anxiety-like behaviors in our mouse model of tauopathy. Additionally, we found that CLU dramatically inhibited tau fibrilization using an in vitro assay. Together, these results demonstrate that CLU plays a major role in both amyloid and tau pathologies in AD.

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The tourism industry has great potential for growth in any economy. Its excessive input-to-output ratio has a significant favorable effect on the economy. Oil costs are affecting the tourism industry because oil fuel prices are a direct factor influencing the tourist industry both demand and supply. There has been demonstrated how the price of petroleum has affected transportation, aviation, and tourism has varied. So, for this purpose, the paper uses a bibliometric analysis method based on Scopus statistics, along with R studio productive methods and Vos viewer for visual results to determine the current trends within the along with oil price's consequence on the tourist industry. The findings used Descriptive analyses, thematic maps, and current trends of issues like oil price shocks and tourism operations to predict the frequency of courses. Lastly, by offering new research directions in sustainable tourism, this bibliometric analysis helps us to draw a conclusion to study.

Objectives: This study aims to find and compare the effects of primal reflex release technique and stretching exercises on pain intensity, functional performance, and pain-free sitting duration in patients with coccydynia. Methods: This is a randomized clinical trial. A total of 46 individuals were chosen for the sample based on the inclusion criteria, and they were divided into groups A and B. Pre-treatment values of patients for pain assessment were taken by the Numerical Pain Rating Scale (NPRS), Dallas Pain Questionnaire (DPQ), and pain-free sitting duration (PFSD). Group A received treatment with a hot pack and primal reflex release technique. Group B received treatment with a hot pack and stretching exercises. Each patient received a total of 12 sessions over the course of 4 weeks, 3 sessions per week. After 4 weeks of therapy, both groups were evaluated again. The obtained data were analyzed using SPSS 21. Results: Findings revealed that within-group differences were statistically significant (P<0.05) for all variables. In the primal reflex release technique group, the average NPRS value reduced from 5.565±1.4086 to 1.7391±1.09617, the average DPQ value from 129.967±33.102 to 38.000±26.691 and the average PFSD duration increased from 43.043±20.323 to 368.478±160.464. In the stretching group, NPRS reduced from 6.087±1.345 to 3.695±1.490, DPQ from 116.032±35.054 to 60.608±22.186 and PFSD increased from 28.260±11.928 to 94.130±102.154. The between-group analysis also indicated statistically significant differences in NPRS, DPQ, and pain-free sitting duration with P values ≤0.001, 0.003, and ≤0.001, respectively Discussion: The study concluded that both the primal reflex release technique and stretching exercises were effective in reducing pain and improving functional status with a marked increase in pain-free sitting duration. However, the primal reflex release technique was found to be more useful than stretching exercises in terms of mentioned outcome measures on basis of their mean differences.