Introduction: To evaluate effectiveness and patient satisfaction of the local anesthesia and intravenous sedation in the patients undergoing diagnostic and therapeutic arthroscopy of knee. Methods: We conducted prospective study in 62 consecutive diagnostic and therapeutic knee arthroscopies in patients between the ages of 18 to 60 years. Visual analogue pain score (VAS) from 0 no pain to 10 worst pain was used for evaluation of pain at the time of local anesthetic injection, during procedure, 30 min, 2 hour and 4 hours post operative period. Patient satisfaction, complications and conversion to other mode of anesthesia was also recorded. Results: In our study 95% (n=57) patients experience no or mild pain during procedure mean VAS of 2.01±1.40. Intra articular and portal site injection was more painful than arthroscopic procedure itself VAS Score 3.43 ± 1.38, two patients (03.22%) planned for both medial and lateral partial meniscectomy and one patient (01.61%) planned for lateral meniscectomy and synovial biopsy had severe pain and were converted to general anesthesia. We did not notice any other complication attributed to local anesthesia or sedation given to patients. Conclusion: Local anesthesia plus intravenous sedation is safe, inexpensive,
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