Background: Phaeochromocytoma is a rare catecholamine producing tumor of the adrenal gland. The anaesthetic management for the excision of this tumor can be challenging because of the haemodynamic fluctuations encountered preoperatively, during induction of anaesthesia, manipulation of the tumor and after the excision of the tumor.Objective: To report a case of a 36-year-old Nigerian female who presented with phaeochromocytoma for surgical excision.Methods: Combined general and epidural anaesthesia was used in the patient. Preoperatively, the patient presented with high blood pressure which was adequately controlled with alpha and beta blockers. Intraoperatively she developed severe hypertension during the manipulation of the tumor this was managed pharmacologically with labetalol, Magnesium sulphate and epidural anaesthesia while hypotension that developed after the excision of the tumor was managed with intravenous fluid and vasopressors. Postoperatively she was transferred into the intensive care unit for monitoring and pain management, she made an uncomplicated recovery. Conclusion:It is therefore required that the anaesthetist be familiar with the physiology of the disease and pharmacology of drugs to treat the fluctuating haemodynamics to achieve a good outcome.
Introduction: Neo-adjuvant chemotherapy (NAC) is increasingly used in the treatment of patients with large and locally advanced breast cancer (LABC). It aims at downsizing the primary tumor thereby minimizing micro-metastatic disease. There exists variable response following neo-adjuvant chemotherapy and the objective of this study was to determine the potential role of breast ultrasound in monitoring the clinical response of LABC to NAC.Methods: One hundred and twenty (120) consecutive patients with LABC scheduled to have six cycles of anthracycline-based neo-adjuvant chemotherapy were recruited for the study at the Surgical Oncology Unit of the University College Hospital, Ibadan. Eligible patients had a pre-chemotherapeutic breast ultrasound (US). Follow up breast US was performed 3 weeks after completion of each cycle of chemotherapy. Ethical approval was obtained from the
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