Phosphonylation of salicin has been achieved using inorganic disodium diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of salicin with DP is salicin : DP = 0.1 mol/L : 1.0 mol/L, pH 12 and 25 ºC. 2', 4'-Diphosphonylsalicin was synthesized with the yield of 50 %. We have successfully introduced the two phosphonate groups in one molecule. The reaction mechanism of salicin with DP was discussed.
We report the case of a 23-day-old neonate who presented at our center with a history of an erythematous lesion on the nose immediately after birth. The infant was born at a gestational age of 40 weeks and 2 days, with a body weight of 3,062 g. On initial examination, the erythema extended from the dorsum of the nose to the columella and ala (Fig. 1A). On the same day, the erythema was irradiated with a variable-pulse-width dye laser (Vbeam ® , Syneron Candela, Tokyo, Japan) with a pulse width of 20 msec and irradiation energy density of 11 J/cm 2 . However, this approach was ineffective. One week later, no ulceration was observed as a complication of the laser treatment. At 6 weeks of age, the hemangioma protruded and small ulcers developed in the right ala, which deformed the right nostril (Fig. 1B). Subsequently, the ulcers expanded; hence, the administration of propranolol (2 mg/kg/day) was initiated 9 weeks after birth. The ulcer healed 3 weeks after
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