IntroductionAcne scarring is a common undesirable complication of acne vulgaris. Fractional erbium-yttrium aluminum garnet (YAG) 2940 nm laser and platelet-rich plasma have been used in treating acne scars with variable outcomes. The objective of this study is to assess the efficacy of fractional erbium-YAG 2940 nm laser and platelet-rich plasma as a single line of treatment in comparison with combined treatment in atrophic postacne scars.MethodsSeventy-five patients were included in this trial and randomized into three equal groups (25 each). Group A was subjected to six sessions of erbium-YAG laser for 6 months, group B was treated with 12 sessions of platelet-rich plasma over the same period, and group C was subjected to six sessions of erbium-YAG laser plus 12 sessions of platelet-rich plasma over the same period. Each subject was evaluated by acne scar grading, photography, and subjective evaluation.ResultsBoth treatment modalities showed improvement of acne scars, but the improvement with combined treatment was better than that with erbium-YAG laser or platelet-rich plasma alone regarding scar grade improvement (P = 0.007 and 0.001), clinical improvement (P = 0.001 and 0.001), and patient satisfaction (P = 0.005 and 0.001), respectively.ConclusionsThe combination of platelet-rich plasma plus erbium-YAG laser is superior to either treatment alone for acne scars, with trivial side effects for all treatment modalities.Trial RegistrationClinicalTrials.gov identifier; NCT03933033.
Mercury is given particular attention, because of its detrimental impacts on both human and animal health. It is claimed that it accumulates in the liver, causing liver toxicity and tissue damage. Consequently, it was intended in the current research to explore the potential antioxidant activity of coenzyme Q10 (CoQ10) against mercuric chloride (HgCl2)-induced hepatotoxicity. Twenty-eight male albino rats were divided into four groups: control group; given saline, CoQ10 group; given CoQ10 (10 mg/kg b.wt.); HgCl2 group; given mercuric chloride (1 mg/kg b.wt.); and the co-treated group, given coenzyme Q10 (10 mg/kg b.wt.) plus HgCl2 (1 mg/kg b.wt.). All treatments were received orally for 4 weeks. The HgCl2 group had significantly higher serum concentrations of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase enzymes, while total protein and albumin values were significantly decreased. Rats also showed a significant increase in mercury concentration and exhibited a notable spike of lipid peroxidation levels with concurrent declines in antioxidant enzyme (GSH). This result was concomitant with histopathological changes of examined liver tissues. Treatment with Co-treatment with CoQ10 ameliorated the hepatotoxicity induced by HgCl2 as indicated by improved serum biochemical parameters, oxidative markers, histopathological features of hepatic tissues. In conclusion, CoQ10 could be the best choice to counteract the liver toxicity produced by mercuric chloride exposure through its antioxidant effect.
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