Nanoparticles (NPs) have biological activities like antibacterial, antifungal, drug delivery, immunomodulation and antitumor activities. The aim of the current study was to investigate some of biomedical applications of silver NP synthesis using extracts from leaves of Eriobotrya japonica. Colour changes, UV-visible spectroscopy, SEM, zeta potential, dynamic light scattering, FTIR and XRD were used to confirm AgNPs formation. The UV-vis spectrum absorption band was observed at almost 430 nm. The SEM image shows quasi-spherical shape of AgNPs. The zeta potential demonstrated the negative surface charge of NPs. FTIR results showed the functional groups of AgNPs. Crystalline nature of AgNPs was confirmed by XRD pattern. MTT assay was used to study the anti-proliferative activity against MCF-7 and HeLa cells. Apoptosis was tested using a DNA-fragmentation test, and expression of P 53 . AgNPs inhibited the proliferation of MCF-7 and HeLa cells, and reduced inflammation. Treatment with AgNPs significantly decreased allergic disorder. AgNPs stimulated the phagocytosis process in BMDMs. The results suggested that AgNPs could be a promising therapy for future and preventing inflammation, reduce allergic disorders and prevent bacterial infection through the up-regulation of phagocytosis. Hence, future work such as developed and improved NPs as adjuvants, immune-modulating substances and nano-drug delivery system is needed.
This study was done for the purpose of detecting the active compounds in the aqueous extract of the plant leaves for Eriobotrya japonica that is one of evergreen plants and medicinal plants, which has the advantage, that possess therapeutic properties and pharmacological effects which are beneficial for human body. These plants are found naturally produces secondary metabolites, such as alkaloids, flavonoids, resins and ect. Effective compounds have been detected by the use of chemical reagents and solvents such as Benedict's reagent and Mayer's reagent, mercuric chloride solution and 1% ferric chloride solution, ect. Also, the effect of the extract as an antioxidation factors has been studied by using the experience of aqueous extract of the leaves Eriobotrya japonica plant that effect on the molecule of DNA in vitro. The results showed that the aqueous extract of the plant leaves for Eriobotrya japonica contains compounds such as Alkaloids, Phenols, Flavonoids, Terpenes, Steroids, Saponins, Resins and Glycosids. Therefore, it can be concluded that the plant of Eriobotrya japonica is one of medicinal plants because it contains the active compounds with medical property, especially, phenols, flavonoids and alkaloids as antioxidant compounds.
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