This review highlights a decade-long journey of Au-catalyzed 1,2-difunctionalization reactions of C–C multiple bonds that have been realized due to the productive integration of Au(i)/Au(iii)catalysis with unique π-activation mode of gold complexes.

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C–N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au­(III) intermediates.

Reported herein is a ligand-enabled gold-catalyzed C(sp 2 )−O cross-coupling reaction of aryl iodides and aliphatic alcohols. The synthesis of a variety of aryl alkyl ethers including complex biomolecules and various medicinally relevant motifs has been achieved to demonstrate the usefulness of the method. The importance of gold catalysis has been highlighted by overcoming the selectivity issues that are in general observed for C−O crosscoupling reactions when other transition metals are used as catalysts.

Transition metal-catalyzed enantioselective functionalization of ubiquitous CÀ H bonds has proven to be promising field as it offers the construction of chiral molecular complexity in a step-and atom-economical manner. In recent years, gold has emerged as an attractive contender for catalyzing such reactions. The unique reactivities and selectivities offered by gold catalysts have been exploited to access numerous asymmetric transformations based on gold-catalyzed CÀ H functionalization processes. Herein, this review critically highlights the major advances and discoveries made in the enantioselective CÀ H functionalization under gold catalysis which is accompanied by mechanistic insights at appropriate places.

Reported herein is a ligand-enabled gold-catalyzed C(sp2)-O cross-coupling reaction of aryl iodides and aliphatic alcohols. The synthesis of a variety of aryl alkyl ethers including complex biomolecules and various medicinally relevant motifs has been achieved to demonstrate the usefulness of the method. The importance of using gold catalysis has been highlighted by overcoming the selectivity issues that are in general observed for C-O cross-coupling reactions when other transition metals are used as catalysts.