A mechanoresponsive, viscochromic, and unsymmetrical azine NDEA probes Al3+ and Cu2+ ions and also co-localizes in the mitochondria of C6 glioma cell lines.
A new rhodamine-based
probe 3,5-di-tert-butylsalicylaldehyde rhodamine
hydrazone (RHTB) has been synthesized and well characterized
using spectroscopic
techniques and single-crystal X-ray crystallography. Among several
metal ions, it selectively detects Cu2+ ions as monitored
by UV–Vis and emission spectral titrations. It displays “turn
on” behavior owing to the opening of a spirolactum ring and
the presence of 3,5-di-tert-butyl as an electron
releasing group. Further, Cu2+ ions play a pivotal role
in extracellular aggregation of Aβ42 peptides. So
far, we know probably that there are no promising drugs available
in this regard. Hence, countering the Cu2+ ions by RHTB chelation against orally administered Cu2+ ion-induced neurotoxicity in the eye tissue of Drosophila expressing human Aβ42 (amyloid-β42) has been tested. The present study involves in vivo and in silico approaches. They reveal the therapeutic
potential of RHTB against Cu2+ ion-induced
Aβ42 toxicity in Alzheimer’s disease (AD)
model of Drosophila.
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