A synthetic scheme for the solid-phase synthesis of unprecedented polythioether dendrons has been established, the dendrons prepared up to the fourth generation, and the applicability of the dendronized resins for supported catalysis has been demonstrated.
Chiral Pybox (pyridine-2,6-bis(oxazoline)) ligands can be cleanly and efficiently prepared on polystyrene support via a five-step solid-phase synthetic sequence. Cu(I)-complexed polymer-bound Pybox was used as a catalyst in the first heterogeneously catalyzed asymmetric addition of alkynes to imines. Best enantioselectivity was observed with (t)Bu-substituted oxazolines.
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