We examined symptoms of posttraumatic stress disorder (PTSD) in adolescent survivors of childhood cancer and their mothers and the contribution of family functioning, including perceived emotional support and familial conflict, and individual factors including life stress and severity of disease to PTSD symptoms. Participants were 52 adolescent cancer survivors and their mothers and 42 healthy adolescent counterparts and their mothers. Findings revealed that mothers of cancer survivors endorsed more PTSD symptoms than did their healthy counterparts and that survivors and mothers also reported greater recent and past stressful life events. Although no survivors met clinical criteria for a PTSD diagnosis, over 36% endorsed mild subthreshold symptomatology. Findings are discussed in the context of understanding PTSD symptoms within a family systems framework.
BACKGROUND-Outcomes in children and adolescents with recurrent or progressive highgrade glioma are poor, with a historical median overall survival of 5.6 months. Pediatric highgrade gliomas are largely immunologically silent or "cold," with few tumor-infiltrating lymphocytes. Preclinically, pediatric brain tumors are highly sensitive to oncolytic virotherapy with genetically engineered herpes simplex virus type 1 (HSV-1) G207, which lacks genes essential for replication in normal brain tissue.
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