It is widely accepted that human thyrotropin causes lipolysis in fat cells isolated from a variety of sources. An investigation into the use of this lipolytic activity as a means of tracing thyrotropin through a fractionation procedure revealed that the biological and lipolytic activities of this hormone are separable and are probably, therefore, caused by two different entities. It is obvious that the measurement of lipolysis is an unsuitable assay for thyrotropin. It was shown that this lipotropic compound is antigenic and likely also to interfere with the accuracy of a radio‐immunoassay for thyrotropin.
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