A radical relay strategy for mono- and di-halogenation (iodination, bromination, and chlorination) of sp3 C–H bonds has been developed. This first example of double, geminal C–H functionalization is enabled via iterative, hydrogen atom transfer (HAT) by in situ generated imidate radicals.
International audienceA collection of phosphine oxide allenes has been prepared. Their coordination to gold(I) has been studied giving new coordination complexes when a pendant pyridine moiety was present. Alternatively, their gold(I)-catalyzed cycloisomerization has proven to be quite efficient. An almost complete axial-to-central chirality transfer in the cyclization process was observed, opening the potential access to valuable enantiopure phosphorus derivatives
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