Metallic implants for ostheosynthesis are used for temporary replacement of the the original functions and to accelerate the bone consolidation after fracture. Stainless steel is frequently used for bone fracture fixation in spite of its sensitivity to corrosion in aggressive environments such as human body 1. This study is focused on the effect of associated use of various metallic implants for osteosynthesis and the occurrence of local adverse reactions as a tissue response. Once the degradation process occurs metal ions are released and are held responsible for these undesirable effects. This was the main motivation of starting a comprehensive study which involved the clinical data of patients who underwent such surgery, analysis of tissues around the implants and also investigation of metallic explants through microscopy techniques.
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