Background:Combination of Nephrolepis exaltata - Hibiscus rosa sinensis (NEHRS) herbal mask proved to decrease nasal mucociliary transport time, increase sinonasal IgA and lung function in textile industry workers. Its protection effect on motorcycle taxi drivers exposed to acute motor vehicle exhaust pollutants has not been proven. The study aimed to demonstrate the protective effect of using NEHRS herbal mask both in the sinonasal immune system and lung function.Methods:This research was non-blinded randomized control trial with pre-post test design. Thirty two motorcycle taxi drivers were randomly assigned into three groups; positive control (n=11) using regular medical mask, negative control (n=10) using nonwoven cloth mask, and intervention group using NEHRS herbal mask (n = 11). Nasal wash was taken by ENT specialist, and the level of sinonasal IgA and IL-6 was reading by ELISA. Pulmonary function parameters were performed using the MAS-1-A spirometer, Data were analyzed with Wilcoxon, Paired t-test, Mann Whitney and One-way ANOVAResults: Sinonasal IgA level were significant decrease in all groups, respectively; intervention 16.31 ± 3.38; control (+)16.24 ± 2.62; control (-)15.28 ± 2.50. The IL-6 level also decrease in all groups in significantly difference (p=0.031), the delta were; intervention -6.92 ± 8.61; control (+) -10.23 ± 7.65; control (-)-8.56 ± 4.37. A significant increased of FEV1 (p=0,005) and PEF (p = 0,005) in the intervention group, but nearly significant of FVC (p=0,053), as well as in control (+); FVC (p=0,017), FEV1 (p=0,005), PEF (p<0,001), and control negatif; FVC (p=0,046), FEV1 (p=0,010), PEF (p=0,005). The test for difference of increasing FVC (p=0,652), FEV1 (p=0,696) and PEF (p=0,670) between all groups not significantly different.Conclusions: NEHRS Herbal mask that worn by motorcycle taxi drivers for 2 weeks decreased IgA and IL-6 sinonasal levels, as well as increased FVC, FEV1, and PEF.
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