The incidence of hyponatremia in this population was high and progressive over time. Negative sodium balance in the first 12 postoperative hours and then a positive fluid balance could be associated with the development of postoperative hyponatremia.
PIM2 showed an adequate discrimination between death and survival and a poor calibration assessed by the Hosmer-Lemeshow goodness-of-fit test. The standardized mortality ratio and clinical analysis of the Hosmer-Lemeshow table make us consider that PIM2 reasonably predicted the outcome of our patients.
The implementation over 2 years of a ventilator-associated pneumonia prevention bundle specifically adapted to our unit using quality improvement tools was associated with a reduction in ventilator-associated pneumonia rate of 25% every 6 months and a nil rate in the last semester.
The PELOD score is reproducible, has excellent discrimination, but over-predicts mortality and has poor calibration. Although the lack of calibration may not invalidate the score, the PELOD score is a discontinuous variable and we advise careful consideration when using it as a surrogate endpoint in clinical trials.
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