Background and aims The aim of this study is to determine the effects of adjuvant immunoglobulin M-enriched IVIG therapy on mortality rate, haematological variables and length of hospital stay in newborn infant with blood culture-proven sepsis. Methods Demographic and clinical features and outcome measures of 63 newborn infant with blood culture-proven sepsis were retrospectively documented from the medical records. The patients were divided into two groups according to their treatment history. The patients in Group 1 received antibiotic therapy only and the patients Group 2 received both antibiotic and adjuvant IgM-enriched IVIG. Results The study revealed that mortality rates were 28.1% and 12.9% in Group 1 and Group 2, respectively. The mortality rate was lower in group 2, but the difference between the two groups was not statistically significant (p = 0.21) Coagulase negative Staphylococcus was the most common type of bacteria isolated from blood culture in both groups. When compared changing of laboratory results in both groups, haemoglobin, leukocyte count and CRP levels were different between two groups during the first three days of antibiotic treatment. Conclusion Our study revealed that if diagnosed at an early stage and treated aggressively with appropriate and effective antibiotics, adjuvant IgM-enriched IVIG treatment have no additional benefits in neonatal sepsis.
neuroprotective agent. The aim of this study was to explore the neuroprotective properties of CBD after hypoxia ischemia in newborn piglets. Materials and method 54 anaesthetised piglets (age 12-36 h) were randomised to either undergo global hypoxia (n = 48) until the base excess reached -20 mmol/L or the mean arterial blood pressure dropped below 20 mm Hg or to the SHAM group (n = 6). After hypoxia piglets were randomised to the different study groups : Hypoxia+CBD (1 mg/kg) (n = 12), Hypoxia+CBD(1 mg/kg)+hypothermia (n = 12), hypoxia (n = 12) or hypoxia+hypothermia (n = 12). 9,5 h after end of hypoxia the piglets were euthanized and samples from hippocampus were snap frozen in liquid nitrogen. Levels of lactate (lac), n-acetylaspartate (NAA) and glutamate (glu) were measured by protonmagnetic-resonance-spectroscopy (H ± -MRS)-and ratios predictive of neurodevelopmental outcome after hypoxic-ischaemic encephalopathy in newborns where calculated (lac/NAA and glu/ NAA). Outliers > 2,5 SD away from mean were removed before analysis. Results Discussion Hypoxia significantly increased both Lac/NAA and Glu/NAA ratios. Hypothermia groups were comparable to SHAM while there were no significant effects of CBD on these MRS biomarkers. The difference in the way of inducing and the severity of hypoxia-ischemia in our model might explain this lack of effect compared to previously published studies.
Results We found significantly higher serum ADMA levels but not serum hs-CRP levels in NBF when compared to BF group (p < 0.05). According to BMI data starting from the age of 12 months more overweight/ obese children were found in NBF children when compared to BF. Serum ADMA was inversely associated with HDL-cholesterol levels and breastfeeding duration in studied children (p < 0.05). Positive correlation was found between ADMA and body fat mass (p < 0.05). Conclusion In NBF children increased circulating ADMA is observed, however further studies are needed to assess whether breastfeeding duration affects body fat and other measures of body composition at older ages. Background and aims Anti cholinergic and sympathomimetic eye drops are widely used to achieve mydriasis. Normally systemic effects of these eye drops are ignorable but adverse events in preterm infants are reported. In this study during routine screening for retinopathy of prematurity (ROP), preterm infants were searched for the systemic effects of eye drops. Methods The standard protocol was to instil 3 drops per eye which is a mixture of short acting tropicamide 0.5% with long acting cyclopentolate 1% and phenylephrine 2.5% ophtalmic solution in equal volumes. Each drop instilled at a 15 min interval before examination. Body temperature, heart rate, respiration, blood pressure, spO2, presence of flashing were recorded three times; before the instillation of eye drops, just before the examination and after an hour. Parents were informed about the adverse side effects and presence of complaints were asked after 24 h with the telephone interview. Data were analysed by 2 twoway ANOVA and independent samples t-test. Results Forty eight (27 male+21 female) infants with birth weight 1498 ± 432(720-2500)g and gestational age 31,7 ± 3.3 (25-37)weeks were examined at postmentruel age of 41. 95 ± 4.74(34-58) weeks. Body temperature rised subsequently with each eye drop (p = 0.023). The change in other physiologic parameters were not statistically significant. Apnea over10 seconds were developed in 9 infants. Within 24 h gastrointestinal symptoms developed in 8, discomfort/sleeplessness in 22, hyperemia/discharge from the eye in 20 infants. Conclusion It was concluded that doctors must be aware of the the systemic effects of mydriatic eye drops used in screening examination for ROP and parents have to be informed about these effects. PO-0713 SYSTEMIC EFFECTS OF ANTICHOLINERGIC - SYMPATHOMIMETIC EYE DROPS DURING SCREENING FOR RETINOPATHY OF PREMATURITY
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