Cancer diagnosis and classification is extremely complicated and, for the most part, relies on subjective interpretation of biopsy material. Such methods are laborious and in some cases might result in different results depending on the histopathologist doing the examination. Automated, real-time diagnostic procedures would greatly facilitate cancer diagnosis and classification. Laser-induced breakdown spectroscopy (LIBS) is used for the first time to our knowledge to distinguish normal and malignant tumor cells from histological sections. We found that the concentration of trace elements in normal and tumor cells was significantly different. For comparison, the tissue samples were also analyzed by an inductively coupled plasma emission spectroscopy (ICPES) system. The results from the LIBS measurement and ICPES analysis were in good agreement.
Double-pulse laser-induced breakdown spectroscopy of magnesium in water has been performed with different jet thicknesses. A Meinhard nebulizer has been used to create a jet of 0.3-mm diameter, whereas a homemade liquid jet injector produced a thicker jet of 1.0-mm diameter. The relationship of line intensity to delay time between the two laser pulses for these two jets is compared and discussed. The limits of detection in these two jets are also determined and compared. The line intensity observed from the double-pulse measurement is correlated with the measured electron density calculated with the Halpha line. Also, the behavior of plasma density relative to time delay between the lasers is described.
Effects of a steady magnetic field on the laser-induced breakdown spectroscopy of certain elements (Mn, Mg, Cr, and Ti) in aqueous solution were studied, in which the plasma plume expanded across an external steady magnetic field (approximately 6 kilogauss). Nearly 1.6 times enhancement in the line emission intensity was observed in the presence of the magnetic field. The temporal evolution of the line emission showed a significant enhancement in plasma emission between 2- and 7- micro(s) gate delays for Mg in the presence of the magnetic field (5-30 micro(s) for Mn). This enhancement in the emission is attributed to an increase in the rate of recombination because of an increase in plasma density due to a magnetic confinement after cooling the plasma. The increase in the optical line emission due to magnetic confinement was absent when the plasma was hot with a dominant background (continuum) emission. The limits of detection of Mg and Mn were reduced by a factor of two in the presence of a steady magnetic field of 5 kilogauss.
The bit error rate expression of the binary phase‐shift keying modulation scheme has been derived in a frequency selective fading channel for the fractional Fourier transform (FRFT) based orthogonal frequency‐division multiplexing (OFDM) system in the presence of carrier frequency offset (CFO). The performance of the FRFT based OFDM system has been found to be better than FFT‐based OFDM at different values of FRFT angle parameter ‘α’.
-Generalized Frequency-Division Multiplexing (GFDM) is one of the multicarrier modulation schemes currently under study for next generation 5G cellular networks. One of the main characteristics of GFDM is the low out of band emission that is achieved by means of a flexible time-domain pulse shaping of individual subcarriers. In the paper, we propose to use improved Nyquist pulse shaping filters which have been originally introduced in the context of single-carrier modulation schemes for reducing the sensitivity to symbol timing error due to their higher eye opening and smaller maximum distortion. Here we consider their use in GFDM and evaluate their symbol error rate (SER) performance in case of 16-QAM transmission over an additive white Gaussian noise channel. Moreover, we also considered the concept of the wavelet for better time-frequency localization of the pulse shaping filters by using the Meyer auxiliary function. Numerical results are reported to demonstrate the superior SER performance achieved by the proposed improved Nyquist pulse shaping filters in comparison to that achieved with conventional Nyquist pulse shaping filters.Keywords -Generalized frequency-division multiplexing (GFDM); Nyquist filtering; symbol error rate (SER).
The laser-induced breakdown spectroscopy of magnesium, manganese, and chromium atoms by use of a commercial Meinhard nebulizer originally designed for inductively coupled plasma measurements is described. This is the first time, to our knowledge, that this nebulizer has been used for laser-induced breakdown spectroscopy measurements. The limit of detection is slightly lower when the nebulizer rather than a liquid jet is used in single-pulse laser excitation. In addition we present the response characteristics of the nebulizer, such as effects of variations in purge gas and liquid flow rate, that are different from normal operating specifications. The effects of gate delay, gate width, and laser power variations were also studied. The objective of the present research has been to consider a new operating mode and conditions in which a better limit of detection of trace elements in water can be obtained.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.