Famciclovir is a guanine analog antiviral drug used commonly for herpes zoster. Efficacy of famciclovir treatment has been reported to be comparable to valacyclovir treatment. Both of these medications reduce the time to complete cessation of zoster-associated pain including post-herpetic neuralgia, as compared to acyclovir. We conducted a multicenter, randomized, open clinical trial in order to evaluate the extent of pain relief afforded by these two antiviral drugs during the acute disease phase of herpes zoster. The study group comprised 86 immunocompetent adult patients suffering from herpes zoster, who were treated with either famciclovir or valacyclovir for 7 days. Of these, 55 patients enrolled in this study within 72 h of the onset of the rash and 31 patients after 72 h of the onset. There was a significant reduction in acute herpes zoster pain with famciclovir on day 7 and at 2-3 weeks in both of these patient groups, while with valacyclovir, there was not significant reduction in pain on day 7. Of patients aged 50 years or older, there was a significantly earlier reduction in pain with famciclovir than with valacyclovir. In addition, a significant reduction in the number of patients with pain was observed as early as days 3-4 with famciclovir treatment as compared with valacyclovir treatment. We conclude that famciclovir was superior to valacyclovir in the relief of acute pain of herpes zoster. Accordingly, famciclovir is recommended for herpes zoster patients with moderate symptoms and a visual analog scale score of under 50 mm.
Even though lichen pilaris has been conventionally treated with topical preparations such as urea ointment, salicylic acid, petrolatum and vitamin A ointment and the like, none of these therapeutic approaches has been reported to achieve good and consistent results. In addition, this may be a disorder for which the necessity for treatment tends to be underestimated since the symptoms are is said to decrease with age and almost disappear spontaneously by the time the patients are in their 30s. However, spontaneous regression can take a longer period of time till full disappearance, prompting quite a few patients to visit clinics from the cosmetic perspective of the condition. The Q-switched Nd: YAG laser (QSNY) has been wellreported for the successful treatment of pigmented cutaneous lesions and for skin rejuvenation. The present study therefore trialled the application of the QSNY in a case of lichen pilaris. Only a few treatments have been reported as significantly effective, so often natural resolution over time is the only option. The present study examined the use of a 1064 nm Q-switched Nd:YAG laser (QSNY) in quasi long-pulsed mode, in an attempt to treat a case of lichen pilaris. Subject and Methods Subject and condition Subject and Methods:A 33-year-old male presented with light-brown aggregated papules observed on both sides of the upper arms. The affected areas were treated every other week (QSNY, pulse width 300 µs, pulse energy 3.0 J/cm², spot size 6 mm and repetition rate 10 Hz). Clinical photography was taken of the lesions at baseline and three months after the final treatment in addition to macrophotography and 3-D photography, biopsies being taken at both time points for histological comparison. Results:The clinical photography and objective image evaluation demonstrated shrinkage of pores and improvement of the unevenness of the skin. Histological examination suggested that the effect of the micropulsed QSNY on the horny layer, epidermal keratinocytes and dermal collagen resulted in a peeling effect and increased dermal collagen density, which eventually led to the shrinkage of the pores and improvement of the skin condition. Conclusions:The results of this single patient case report suggest that the micropulsed QSNY could be an effective treatment option for lichen pilaris, improvement of which is often difficult.Further studies with an appropriately-sized population are merited to confirm these preliminary results.
要旨 赤外線と高周波である radiofrequency を同時照射できる装置 (ST リファームTMapplied to the fat vanish weight loss method and its effect and the mechanism of action for tightening was investigated in this study Seven obese male patients whose abdominal circumference is more than 85 cm were selected as a test subject First of all IR-RF was continuously irradiated to approximately 1% of the umbilical region The measurement of body weight abdominal circumference and blood pressure thermograph and all sorts of blood tests and measurement of the size of abdominal fat by Computed Tomography (CT) were carried out before and 30 min and 60 min after the irradiation Then the changes in these parameters were examined The body weight and abdominal circumference showed declining trend from 30 min after the irradiation Time-course changes were found in the catecholamine system and lipid / carbohydrate metabolism In the case which showed radical decline of body weight and abdominal circumference the trend of declining visceral fat was also observed by CT This methodology is expected to be a one of the treatment choices in new territory of obese treatment for the future It was found out that metabolism changes in catecholamine and lipid / carbohydrate systems will occur during IR-RF irradiation The possibility of contribution of this influence particularly on a fat cell to tightening was suggested
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