Atsusuke Terada scite author profile

[(Cycloalkylmethyl)phenyl]acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities. Some of the compounds in this series were found to have good activity in the carrageenan edema test. Among them, sodium 2-[4-[(2-oxocyclopentyl)methyl] phenyl]propionate dihydrate (15) and 2-[4-[(2-oxocyclohexylidene)methyl]phenyl]propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.

Synthesis of inhibitors of bacterial cell wall biogenesis. Analogs of D-alanyl-D-alanine

Smissman¹,

Terada²,

El-Antably³

1976

J. Med. Chem.

Studies on Benzodiazepinooxazoles. IV. The Formation of Quinolones by the Ring Contraction of a Benzo [6, 7]-1, 4-diazepino [5, 4-b]-oxazole Derivative

Terada

Yabe

Miyadera

et al. 1973

Treatmentof 10-chloro-2,3,5,6,7,11b-hexahydro-7-methyl-11b-phenylbenzo [6,7] -1,4-diazepino [5,4-b]oxazol-6-one (IV) with sodium hydride in dimethyl acetamide gave the two compounds, 6-chloro-3-(2-hydroxyethyl)-1-methyl-4-phenyl-2(1H)-quinolone (V) and 6-chloro-3-hydroxy-1-methyl-4-pherryl-2(1H)-quinolone (VI). A mechanistic assumption for the formation of V was discussed.In the past few years, it has been reported that 1,4-benzodiazepines undergo rearrangements leading to isoindoles,1,3) indoles,4) quinazolines,5-7) quinoxalines8) and quinolines.9)In the preceding paper, we have reported1 on the base-catalyzed intramolecular rearrangements of benzo [6,7]-1,4-diazepino [5,4-b] oxazoles giving isoindole and acridanone derivatives, and on the reactions of I with N,N-dimethyl formamide (DMF) in the presence of sodium hydride affording exo-methylene compounds as shown in Chart 1. Our interest in the for-

Studies on Acetylenic Compounds. XLVI. The Reactions of Acetylenic Compounds with Thiourea or Ammonium Dithiocarbamate

Kishida

Terada

1968

Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives

Amemiya

Terada²,

Wachi³

et al. 1989

J. Med. Chem.

1-Imidazolylalkyl-substituted di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives and related compounds were synthesized from tetrahydrobenzo[b]thiophene derivatives (1 or 4) in order to study the structure-activity relationships of the inhibition of thromboxane A2 synthetase in vitro. Sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate (26) and 2-(1-imidazolylmethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-6-carbo xylic acid hydrochloride (28) showed the most potent and specific activity in vitro for thromboxane A2 synthetase inhibition.

European Journal of Pharmacology

Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response

Yamaguchi¹,

Mukaiyama²,

Itoh³

et al. 1993

Structural determination of rat urinary metabolites of sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate (loxoprofen sodium), a new anti-inflammatory agent.

Naruto¹,

Tanaka²,

Hayashi³

et al. 1984

Studies on 1,3-benzoxazines. I. Synthesis of primary 2-amino-pyridines via the reaction of imidoyl chlorides of 1,3-benzoxazines with pyridine N-oxides.

Wachi¹,

Terada²

1980