The inside cover picture, by Kerr and co‐workers, depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N‐heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies. Details of this work can be found in the full paper on .
A regio- and diastereoselective synthesis of 2,3-dihydro-10b′H-spiro[indeno[1,2-b]quinoxaline-11,1′-pyrrolo[2,1-a]isoquinoline]-2′,3′-diylbis(phenylmethanone) derivatives containing four contiguous chiral stereocenters was achieved through 1,3-dipolar cycloaddition of isoquinolinium N-ylides in a one-pot three-component reaction. The desired products were obtained in short reaction times and in moderate to high yields (up to 92%) under relatively mild reaction conditions. The structure and relative stereochemistry of the desired product was confirmed by X-ray diffraction analysis.
An efficient catalyst-free one-pot three-component reaction was developed for the synthesis of a new family of N- and S-containing spirocyclic compounds. Various derivatives of spirobenzimidazolidine containing an indole scaffold were synthesized for the first time in a modestly toxic solvent and under mild reaction conditions. The reaction times were of the order of several minutes, and all the products were obtained in moderate to high yields (overall yields 58–80%).
The reaction of 2‐chloroquinoline‐3‐carbaldehydes with indoline‐2‐thione in ethanol provides a series of novel indolo[3′,2′:5,6]thiopyrano[2,3‐b]quinoline derivatives. The desired products were obtained in short reaction time and high yields (69‐93%) under mild reaction conditions.
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