This study was conducted to develop Chaguro, a low-cost supplementary food made of chayote (Sechium edule (Jacq.) Swartz) and tuna fish (Thunnus sp.), for diabetes and dyslipidemia diet therapy. In order to find a formula with effective hypoglycaemic and antidyslipidemic properties, dried tuna and chayote were mixed at different ratios: F1 (75% tuna, 25% chayote), F2 (50% tuna, 50% chayote), and F3 (25% tuna, 75% chayote). Thirty male Sprague Dawley rats were assigned into healthy control group or groups induced with streptozotocin-nicotinamide and a high-fat diet. Chaguro was administered 2.7 g/ kgBW/ day using a gavage for 28 days. The administration of all Chaguro formulas improved blood markers compared to the negative control group (p < 0.001). Chaguro F2 lowered fasting blood glucose (97.07±1.18 vs 266.31±5.31), total cholesterol (113.59±2.22 vs 208.78±4.31), triglycerides (89.93±2.51 vs 142.35±2.83), LDL-c (33.87±1.87 vs 87.85±3.34) and increased HDL-c (69,08±1,85 vs 23,91±1,64) level the most compared to the negative control group (p < 0.001). Streptozotocin-induced weight loss was also prevented in all diabetic rats fed with Chaguro, with the bodyweight being similar to that of healthy controls at the end of the intervention (p < 0.001). This study found that Chaguro may be a potential food product to help lower blood glucose and improve lipid profile in diabetes and dyslipidemia.
Latar Belakang. Uji sensoris dan uji umur simpan pada pengembangan produk pangan diperlukan agar produk yang dihasilkan dapat diterima dan aman bagi konsumen. Individu yang mengalami prediabetes memiliki kesempatan untuk mencegah atau menunda perkembangan terjadinya diabetes melitus (DM) jika dapat memperbaiki pola hidupnya. Makanan selingan adalah bagian penting dalam manajemen pola makan penyandang prediabetes sehingga jumlah dan jenis bahan makanannya perlu dipertimbangkan. Tujuan. Penelitian ini bertujuan untuk menganalisis dan merumuskan sifat organoleptik dan umur simpan suatu produk makanan selingan untuk penyandang prediabetes. Metode. Penelitian ini menggunakan desain eksperimental dengan rancangan acak lengkap untuk menguji karakteristik sensoris empat formula rasa pada produk makanan selingan prediabetes. Uji pendugaan umur simpan dengan Accelerated Shelf-Life Testing (ASLT) Arrhenius melalui pendekatan nilai angka thiobarbituric acid (TBA) dilakukan pada produk yang belum diberi rasa. Produk disimpan pada suhu 4°C, 27°C, dan 45°C. Analisis statistik dilakukan dengan uji Kruskall Wallis dilanjutkan uji Post-Hoc Mann Whitney. Hasil. Tidak terdapat perbedaan yang signifikan antar formula pada parameter warna dan aroma sampel, tetapi terdapat perbedaan yang signifikan pada parameter rasa, tekstur, dan nilai keseluruhan (p<0,05). Hasil analisis uji pendugaan umur simpan menunjukkan bahwa persamaan regresi pada orde 1 dapat digunakan sebagai pendekatan untuk memprediksi umur simpan makanan selingan untuk prediabetes. Kesimpulan. Makanan selingan prediabetes yang paling disukai untuk parameter warna, aroma, rasa, dan penilaian keseluruhan adalah formula F3 (bumbu bubuk bawang dan garam), sedangkan formula F2 (bumbu bubuk bawang) adalah yang paling disukai untuk parameter tekstur. Prediksi umur simpan makanan selingan untuk prediabetes pada suhu ruang/normal 30°C adalah 80,97 hari atau sama dengan 2,69 bulan.
Latar Belakang. Pengaturan diet bagi pasien prediabetes merupakan salah satu pencegahan kejadian penyakit diabetes melitus secara dini. Labu siam dan ikan tuna merupakan bahan pangan lokal yang mengandung banyak senyawa di mana mampu menanggulangi masalah diabetes sehingga dapat dimanfaatkan sebagai makanan tabur fungsional. Pengembangan makanan berbasis tuna dan labu siam perlu diperhatikan karena dapat merubah kandungan zat gizi makro maupun mikro dan sifat organoleptiknya. Penelitian ini bertujuan untuk menganalisis zat gizi mikro, makro, dan organoleptik makanan tabur berbasis Tuna dan labu siam untuk terapi diet prediabetes. Metode. Penelitian eksperimental dengan rancangan acak lengkap (RAL) menggunakan 3 formula makanan tabur Chaguro yaitu, F1 (ikan tuna 60% dan labu siam 40%), F2 (ikan tuna 50% dan labu siam 50%), dan F3 (ikan tuna 40% dan labu siam 60%). Penelitian ini juga menganalisis kandungan kadar air dan uji mikroba. Analisis statistik dilakukan dengan uji Kruskall Wallis dan uji Post-Hoc Mann Whitney untuk melihat perbedaan tingkat kesukaan dari tiap formula makanan tabur. Hasil. Hasil uji kadar air pada ikan tuna didapatkan pengeringan ikan tuna selama 10 jam dengan suhu 55°C dan 65°C menghasilkan kadar air yang memenuhi syarat <7 persen yaitu 5,85±0,15% dan 5,96±0,00%, berturut-turut. Pada uji kandungan gizi, kadar abu, kadar protein, kadar lemak, kadar serat kasar, dan Zn dalam 100 g formula Chaguro F1 masih dalam batas aman untuk dikonsumsi. Berdasarkan uji organoleptik, parameter kenampakan, aroma, tekstur, dan rasa ikan paling kuat adalah Formula F1. Hasil angka lempeng total (ALT) untuk makanan tabur Chaguro yaitu sebesar 5,5 x 103 CFU/gr. Uji mikroba Salmonella sp. dan Escherichia coli pada makanan tabur Chaguro dinyatakan negatif. Kesimpulan. Formula F1 (ikan tuna 60% dan labu siam 40%) merupakan formula yang paling kuat dan memilki sifat dominan ikan dibandingkan dengan formula lain dan sudah memenuhi syarat SNI Abon 01-3707-1995 dari segi kandungan gizi, kecuali kadar air dan ALT.
Background: The study aimed to examine the effect of administering CHAGURO (a product of the combination of siamese pumpkin and tuna-based powder) on the lipid profile in prediabetes individuals with dyslipidemia. Methods: The experimental trial was conducted with two intervention groups, with each group receiving a dose of 7.5g/70kg body weight (BW)/day (low dose) and 15g/70kg BW/day (high dose) for 60 days. Respondents were randomized into intervention groups using simple randomization. Before and after the intervention, pre-test and post-test examinations were performed, factors examined included hemoglobin A1c (HbA1c), lipid profile, blood pressure, food intake with the SQ-FFQ (Semi Quantitative-Food Frequency Questionnaire) interview, body mass index (BMI), and physical activity using International Physical Activity Questionnaires-Short Form (IPAQ-SF). During the intervention, blood pressure and BMI data were taken before and after the study. Statistical analysis included descriptive tests, independent and paired T-tests, and analysis of variance (ANOVA). Results: Compared to the baseline, HbA1c, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides in the two groups did not improve significantly by 60 days. For lipid variables, a significant improvement in the cholesterol/high-density lipoprotein (chol/HDL) ratios were observed when compared against the baseline for the two groups. When comparing the changes between groups, 7.5 g of CHAGURO showed a larger improvement in HDL-C (mean differences: 1.86 mg/dL; 95% CI: -0.86-4.59), compared to 15 g of CHAGURO (mean differences: -3.62 mg/dL; 95% CI: -7.53-0.28). A significant (p<0.05) decrease in the chol/HDL ratio was observed in the 7.5 g CHAGURO group (mean differences: -0.20 mg/dL; 95% CI: -0.39-(-0.01)). Conclusions: CHAGURO can be a functional food alternative to improve the condition of prediabetes people with dyslipidemia. Trial registration: Dr. Sardjito General Hospital (KE/FK/0951/EC/2020), 27/08/2020
Background: The study aimed to examine the effect of administering CHAGURO (a product of the combination of siamese pumpkin and tuna-based powder) on the lipid profile in prediabetes individuals with dyslipidemia. Methods: The experimental trial was conducted with two intervention groups, with each group receiving a dose of 7.5g/70kg body weight (BW)/day (low dose) and 15g/70kg BW/day (high dose) for 60 days. Respondents in each group ranged in age from 30 to 60 years old. Prediabetes was defined as fasting blood sugar levels of 100-125 mg/dL, while cholesterol levels of 200 mg/dL was considered dyslipidemia. The mean baseline HbA1c level for all subjects was 5.5%. Respondents were randomized into intervention groups using simple randomization. Pre-test and post-test measurements were performed for body mass index (BMI), physical activity (using IPAQ-SF), hemoglobin A1c (HbA1c), lipid profile, blood pressure, and food intake (using SQ-FFQ). Statistical analyses performed included descriptive tests, independent and paired T-tests, and analysis of variance (ANOVA). Results: Compared to the baseline, HbA1c, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides in the two groups did not improve significantly by 60 days. For lipid variables, a significant improvement in the cholesterol/high-density lipoprotein (chol/HDL) ratios were observed when compared against the baseline for the two groups. When comparing the changes between groups, 7.5 g of CHAGURO showed a larger improvement in HDL-C (mean differences: 1.86 mg/dL; 95% CI: -0.86-4.59), compared to 15 g of CHAGURO (mean differences: -3.62 mg/dL; 95% CI: -7.53-0.28). A significant (p<0.05) decrease in the chol/HDL ratio was observed in the 7.5 g CHAGURO group (mean differences: -0.20 mg/dL; 95% CI: -0.39-(-0.01)). Conclusions: CHAGURO can be a functional food alternative to improve the condition of prediabetes people with dyslipidemia. Trial registration: Dr. Sardjito General Hospital (KE/FK/0951/EC/2020), 27/08/2020
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