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Key Points• CLL stereotyped subset #2 (IGHV3-21/IGLV3-21) is uniformly aggressive independently of somatic hypermutation status.• The prognosis for non-subset #2/IGHV3-21 CLL resembles that of the remaining CLL cases with similar somatic hypermutation status.An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P 5 .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P 5 .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL. (Blood. 2015;125(5):856-859)

We present the technologies and the theoretical background of an intelligent interconnected infrastructure for public security and safety. The innovation of the framework lies in the intelligent combination of devices and human information towards human and situational awareness, so as to provide a protection and security environment for citizens. The framework is currently being used to support visitors in public spaces and events, by creating the appropriate infrastructure to address a set of urgent situations, such as health-related problems and missing children in overcrowded environments, supporting smart links between humans and entities on the basis of goals, and adapting device operation to comply with human objectives, profiles, and privacy. State-of-the-art technologies in the domain of IoT data collection and analytics are combined with localization techniques, ontologies, reasoning mechanisms, and data aggregation in order to acquire a better understanding of the ongoing situation and inform the necessary people and devices to act accordingly. Finally, we present the first results of people localization and the platforms’ ontology and representation framework.

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Manufacturing companies increasingly become “smarter” as a result of the Industry 4.0 revolution. Multiple sensors are used for industrial monitoring of machines and workers in order to detect events and consequently improve the manufacturing processes, lower the respective costs, and increase safety. Multisensor systems produce big amounts of heterogeneous data. Data fusion techniques address the issue of multimodality by combining data from different sources and improving the results of monitoring systems. The current paper presents a detailed review of state-of-the-art data fusion solutions, on data storage and indexing from various types of sensors, feature engineering, and multimodal data integration. The review aims to serve as a guide for the early stages of an analytic pipeline of manufacturing prognosis. The reviewed literature showed that in fusion and in preprocessing, the methods chosen to be applied in this sector are beyond the state-of-the-art. Existing weaknesses and gaps that lead to future research goals were also identified.

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Lately, we observe an increase in the development of Internet of Things (IoT) systems. The interconnection of multiple devices offers improved solutions in many sectors. In the current paper, we describe the localization framework of a project that incorporates IoT technologies to face unwanted incidents in crowded spaces. The localization framework responds to the scenario of a missing child in crowded outdoor spaces and combines Received Signal Strength Indicator (RSSI), Bluetooth low energy tags and trilateration. The experimental results of trials performed in two outdoor spaces are also reported. This framework is currently being tested in the actual pilot premises.