The present study aims to compare the rate of depressive symptoms and inflammation levels between sexual minorities and heterosexuals. Data were obtained from the National Health and Nutrition Examination Survey from 2005 to 2010. Depressive-related symptoms were measured using the Patient Health Questionnaire-9 scoring system. C-reactive protein was analyzed with the Behring Nephelometer. Of 8538 participants, 95.8% self-reported as heterosexual and 4.2% as sexual minority. Depressive symptoms were reported in 7.1% of heterosexuals compared to 15.8% in sexual minorities (P = 0.001). In heterosexuals, C-reactive protein was higher in those with depressive symptoms compared to those without (P < 0.001). In sexual minorities, similar results were found, however, it was statistically insignificant. The intersection group of black sexual minority females reported the highest rate of depressive symptoms at 33.4%. We found that depressive symptoms were higher in sexual minorities compared to heterosexuals. Furthermore, systemic inflammation was highest in the intersection group of black sexual minority females.
10563 Background: To evaluate incidences and trends of alcohol-associated cancers in United States adults over the last 18 years. Methods: Data was extracted from the United States Cancer Statistics database from 2001 to 2018. SEER*Stat Joinpoint Regression program 4.8.1 was used to calculate incidences and trends. Average annual percentage change (AAPC) was used to describe trends. Based on the ICD-O-3 criteria, liver, colon, oral cavity, esophagus, and pharynx cancers were classified as alcohol-related cancers. Results: Over the last 18 years, the incidence of alcohol-associated cancers decreased overall in males and females by 0.9% every year (p < 0.001). Alcohol-associated cancers increased significantly in younger patients under the age of 39 years old (p < 0.001). Based on race, Black men and women had the highest incidence at 135.17/100,000 followed by 132.50 in White individuals, 105.84 in Hispanic individuals, and 104.28 in Asian individuals. By region, the incidence was found to be the highest in the Midwest at 132.89/100,000 and lowest in the West at 120.33. Based on cancer types, the most common alcohol related cancer was colorectal cancer with an incidence at 36.49/100,000 in 2018, followed by oral cavity cancers at 11.69, liver cancer at 6.76, esophagus cancer at 4.51, and larynx cancer at 2.92. Of all these types of cancers, liver cancer had the highest annual increase at 2.43% (p < 0.001). Using a projection model, we found that liver cancer is estimated to surpass colorectal cancer by the year 2035. On intersectionality analysis, White men and women in the Northeast between the ages of 75-79 had the highest incidence of alcohol-associated cancers at 584.10/100,000 in 2018. However, over the last 18 years, White men and women in the South between the ages of 20-24 had the highest annual increase at 4.08% (p < 0.001). Conclusions: Over the last 18 years, alcohol-related cancers increased in the younger patients, particularly those residing in the South. Liver cancer is increasing at the highest rate.
10534 Background: To evaluate trends of HPV-associated oropharyngeal cancers and HPV infections in the United States. Methods: Data was extracted from the United States Cancer Statistics Public Use Database (USCS) between 2001 and 2017 and the National Health and Nutrition Examination Survey (NHANES) between 2011 to 2016. Data on oropharyngeal squamous cell carcinoma (OSCC) was obtained from the USCS database. HPV vaccination and screening (oral washings) data were obtained from NHANES. Based on CDC guidelines, HPV strains were further subdivided into high-risk strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68). Results: Based on USCS, oropharyngeal cancer incidence rates have increased in males by 1.64% every year (p < 0.001) while remaining stable in females over the last 17 years. Oropharyngeal cancers have increased for all age groups over the age of 55, with the largest increase seen in those between the ages of 65-69 years old (p < 0.001). However, individuals between the ages of 30-34 had the largest decrease in oropharyngeal cancers over the same time period (p = 0.016). Based on race, Whites had the highest incidence rates at 5.12/100,000 followed by 2.99 in Blacks, 2.32 in Hispanics, and 1.11 in Asians. By geographical region, the incidence was found to be the highest in the Midwest with 4.68/100,000 and the lowest in the West at 3.78. Our intersectional analysis showed that White males in the South aged 65-69 had the highest incidence of oropharyngeal cancers at 40.57/100,000 and this same group aged 60-64 had the highest annual increase at 4.65% (p < 0.001). Using the NHANES database, we showed that those with greater than 4 lifetime sexual partners have a 3-fold higher risk of high risk HPV infection compared to those with 4 or under (7.1% vs 1.9%, p < 0.0001). 8.8% of current smokers are infected with high risk oral HPV compared to only 3.9% of non smokers (p < 0.001). The incidence of any HPV infection for those <39 years old was 5.9% in 2011 and 4.7% in 2016 (p = 0.4723). In contrast, the incidence in those > 39 years old was 6.6% in 2011 and 6.4% in 2016 (p = 0.99). On multivariate analysis, males have a 4-fold higher risk of high risk HPV infections compared to females (4.45, 95% CI: 2.94 - 6.74, p < 0.0001). Those with five or more sexual partners have 7-fold higher rate of high risk oral HPV infections compared to those without any sexual partners (7.15, 95% CI: 1.94 - 26.3, p = 0.0039). Furthermore, current smokers (1.81, 95% CI: 1.17 - 2.77, p = 0.0081) and three to four drinks per day (1.63, 95% CI: 1.05 - 2.55, p = 0.0312) have an increased risk of high risk oral HPV infections. Conclusions: Over the last 18 years, oropharyngeal cancers are increasing in individuals over the age of 55, particularly White males residing in the South. Individuals with greater than 4 lifetime sexual partners, current smokers, and those who consume three to four drinks per day have increased HPV infectivity rates.
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