The industrial area produces lots of solid waste materials with CO 2 emission. One of the most effective ways to solve these problems is the utilization of these waste materials. The production process of cements from its raw materials produces a lot of CO 2. The most effective way to decrease CO 2 emission of cement industry is the substitution of a proportion of cement with supplementary cementing materials. Cement blended with metakaolin (MK) is also required as a countermeasure to reduce the amount of CO 2 generation. Metakaolin (MK), Al 2 Si 2 O 7 , is a highly amorphous dehydration product of kaolinite, Al 2 (OH) 4 Si 2 O 5. The aim of our research was to investigate the effect of up to 20 wt% substitutions of OPC by MK on the hydration characteristics of MK-blended cement pastes. The physico-chemical properties of the hardened cement pastes were studied up to 90 days of hydration. The hydration products of some selected samples were investigated using XRD, DTA and DTG techniques. The results indicated that substitution of up to 20 wt% OPC by MK as pozzolanic materials resulted in an increase in the standard water of consistency, acceleration of the initial setting times, high compressive strength values at earlier ages and improvement of the mechanical and durability properties.
Objectives:To review cases of ovarian cysts managed at a University Hospital, and to identify the factors necessitating the use of laparotomy over laparoscopy.Methods:We carried out a retrospective chart review of all cases of ovarian cysts diagnosed and managed at the Department of Obstetrics & Gynecology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia between January 2010 and August 2014. All data collected from medical record charts, patents details, clinical presentations, ovarian cysts description, and pathology type were recorded, and management by laparoscopy or laparotomy was identified. Ethical approval was obtained from ethical hospital committee.Results:There were 244 cases of ovarian cysts during the study period. The age ranged from 3 months to 77 years of age. The parity from 0-6. The height range from 37-180 cm. The weight range from 3-161 kg, and calculated body mass index ranged from 12-47. Out of 244 patients diagnosed, 165 were married (67.4%). Of those, only 16 patients were pregnant (6.6%). The most common presentation was abdominal pain in 142 patients (58.2%). Only 79.9% were ovarian cysts, and 17.5% were either para-ovarian or retroperitoneal. The right ovaries were affected in 63.1%, and only 18.9% were bilateral. The types of ovarian cysts included functional cysts 33.2%, benign cyst-adenoma 19.3%, and dermoid cysts 12.3%.Conclusion:Factors associated with laparotomy management rather than laparoscopy included older age >35, single, pregnant, or patients presenting with abdominal pain, and more than one cyst.
Quinoline derivatives are attracting considerable interest due to their biological importance. In this paper, several 2-amino-4-aryl-6-(quinolin-2-ylthio)pyridine-3,5-dicarbonitrile derivatives are synthesized by adopting a one-pot reaction of quinoline-2-thione, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide in absolute ethanol. The structures of these newly synthesized compounds were determined using different spectroscopic techniques, including elemental analyses, IR, 1 H NMR, and MS. The synthesized derivatives were screened for their antimicrobial and cytotoxic activities. Compounds 4a, 4b, 4d, and 4e exhibited promising antimicrobial activity compared to antibacterial and antifungal standard drugs. Additionally, 4f, 4d, and 4g showed potent cytotoxic activity against both MCF-7 and A549 cells with IC 50 values (6.39-9.3 μM). Our molecular docking results of compound 4f prove good binding affinity toward the three tested proteins as Jak2/ STATA3 inhibition and are in accordance with the RT-PCR mRNA expressions of the compound against MCF-7 cells which downregulated the Jak2 and STAT3 genes, and this may be the proposed mode of action for anti-breast cancer activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.