S. aureus may play an important role as an aggravating factor in AD patients. Reducing the colonization of atopic skin by S. aureus is therefore the best way to reduce superantigen-induced allergic skin inflammation.

Pinpoint irradiation technique by CO₂ LASER is safe and more effective than TCA CROSS technique. Clinical improvement was achieved in all 14 patients without dramatic adverse effects.

No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). The objective of the study was to evaluate the immunological mechanisms and clinical therapeutic effect of using lipid garlic extract (LGE) in the treatment of RMCW. The study included 50 patients with RMCW. They were randomly assigned into two groups: the first group (25 patients) received LGE, and the second group (25 patients) received saline as a control group. In both groups, treatments were made to single lesions, or largest wart in case of multiple lesions, until complete clearance of lesions or for a maximum of 4 weeks. Blood serum was taken at pre-study and at the fourth week to measure tumor necrosis factor alpha (TNF-α) level. A significant difference was found between the therapeutic responses of RMCW to LGE antigen and saline control group (p < 0.001). In the LGE group, complete response was achieved in 96% of patients presenting with RMCW. There was a statistically nonsignificant increase in TNF-α of LGE group versus saline group. No recurrence was observed in the LGE group. LGE as an immunotherapy is an inexpensive, effective, and safe modality with good cure rates for treatment of RMCWs, when other topical or physical therapies have failed.

Apitherapy is effective and a safe treatment for recalcitrant localized plaque psoriasis, when other topical or physical therapies have failed.

No abstract

Background: Inflammatory Acne vulgaris (IAV) involves colonization of Propionibacterium acnes (P. acnes). P. acnes up-regulates of neutrophils, monocytes and lymphocytes with several cytokines being released locally. Objectives: IL-12 is associated with IAV; we investigated whether this association was correlated with the severity of the disease. Material and Methods: Sera of 27 patients with IAV and 27 gender and age matched healthy volunteers were enrolled. IL-12 and C-reactive protein (CRP) were measured in patients' sera with enzyme linked immune sorbent assay (ELISA). The level was correlated with the severity of the disease using Global Evaluation Acne (GEA) scale. Results: IL-12 serum levels in patients with IAV were significantly higher than controls (p<0.05). But, CRP serum levels in patients with IAV were non-significantly different from control. There was non significant difference as regard relation between IL-12 level and severity of disease (p> 0.05), also, non statistical significant difference as regard relation between CRP level and severity of disease (p> 0.05). Conclusion: In IAV, IL-12 may contribute to the host defenses against P. acnes as well as to tissue damage through its various actions of the involved immune cells and inflammatory mediators. Blocking IL-12 production may hold promise therapy in limiting the deleterious effects of IL-12 mediated inflammatory response.