A retrospective analysis was conducted on patients diagnosed with and treated for keratocystic odontogenic tumor (KCOT) at Mashhad School of Dentistry between 1996 and 2006. The patients comprised 44 men and 30 women with a mean age of 27.08 years. Among the total of 83 lesions, 56 (67.5%) occurred in the mandible and 27 (32.5%) in the maxilla. Swelling tended to be the most common complaint (45.8%), while 24.1% of the lesions were diagnosed incidentally. Six patients (8.1%) with a total of 15 lesions had nevoid basal cell carcinoma syndrome; 28 lesions (33.7%) were associated with an impacted tooth, and 12 (14.5%) presented daughter cysts. Sixty-six KCOTs were treated by enucleation [5 recurrences (7.6%)], 6 by marsupialization [2 recurrences (33.3%)] and 11 by marsupialization followed by enucleation (no recurrences). KCOTs in the mandible showed a higher recurrence rate than those in the maxilla (10.7% vs 3.7%). Although the demographics of Iranian patients are closely similar to those of other nationalities, in this series KCOTs tended to develop in younger patients with a peak in teenagers. The posterior region of the mandible showed the highest likelihood of KCOT occurrence and recurrence. Marsupialization followed by enucleation resulted in the lowest recurrence rate.

The average age at the time of diagnosis of NBCCS was 35.12 years. All patients had a minimum of two major criteria. The major criteria with the most frequency were the keratocysts odontogenic tumor (19 patients), and the average number was 6.2. Basal cell carcinoma (8 patients), and the average number was 14.7 calcification of the falx cerebri (17 patients), palmo-plantar pits (14 patients), mild hypertelorism (10 patients), and bilateral cleft lip and palate (1 patient). Only one patient was affected with an unusual case of NBCCS in a 30-year-old man with an associated squamous cell carcinoma of the maxillary sinus. Only two cases of this unusual association have been reported. This case is one of a large family including 14 NBCCS-affected patients.

The calcifying epithelial odontogenic tumor is a benign epithelial odontogenic lesion that accounts for less than 1% of all odontogenic tumors. It is most frequently seen in the posterior areas of the mandible. Extension of this lesion to the maxillary sinus is extremely rare. In this paper, we report the fourth of such cases which has been reported, up to now. This tumor was encased between the right maxillary lateral and canine roots with extension to the maxillary sinus. Histologically, the tumor is composed of sheets of epithelial cells with eosinophilic or clear cytoplasm, intercellular bridges, nuclear pleomorphism, but no mitotic figures, amorphous eosinophilic and calcified materials were seen within the sheets of epithelial cells.

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Objectives:An unsuccessful attempt to reach the apical area or to place the retrograde material is a major difficulty in periradicular surgery. The aim of this study was to compare the histological evaluation of the healing process following an orthograde versus a retrograde application of mineral trioxide aggregate (MTA) as a root-end filling material during apical surgery on cats’ teeth in order to find out whether orthograde placement of MTA before surgery can be used instead of retrograde placement during surgery.Methods:In this experimental study, 24 canine teeth in 12 mature and healthy cats were filled with either MTA or gutta-percha in an orthograde manner. Two weeks later, the teeth with MTA were surgically exposed and resected to the set-MTA within the canals. The teeth previously filled by gutta-percha were also surgically exposed, and retrograde cavities were prepared at the root ends and filled with fresh-MTA. After 8 weeks, the animals were euthanized by vital perfusion. Six-micron histological slices were prepared from samples, stained by Hematoxylin & Eosin, and histologically studied by means of a light microscope. The collected data was analyzed by the Chi-square and the T-test.Results:One of the samples in the fresh-MTA group was omitted during processing because of inappropriate sectioning. In the set-MTA group, 5 out of 12 showed chronic abscess, while in the fresh-MTA group, 2 out of 11 were discovered to have chronic abscess; however, no significant difference was observed (P>.05). Hard tissue healing (cementum, bone, cementum + bone formation) in the set-MTA and fresh-MTA groups were 7 out of 12 and 9 out of 11, respectively. While healing seemed more likely to occur in the fresh-MTA group, the difference was statistically insignificant (P>.05). The magnitude of bone, cementum, or bone and cementum formation showed slight differences between the two groups; however, the figures failed to show any marked differences (P>.05).Conclusions:Orthograde placement of MTA could be used as an obturation material before surgery. In this way, after root-end resection, there would be no need for root-end preparation and filling procedures.