Dysfunctional eating patterns include alterations in experiencing and expressing hunger, appetite and satiety, which may conduct to eating disorders or obesity in the long term. Alterations in hormones such as ghrelin have been suggested to influence emotional eating in women with obesity. In addition, ghrelin-reactive autoantibodies (autoAbs) are present both in healthy individuals and with eating disorders and have been suggested to protect the hormone from degradation and preserve its functional activity. The aim of this study was to evaluate the relationship between IgG ghrelin-reactive autoAbs with dysfunctional eating patterns, subjective perception of stress and body composition parameters in young women. This cross-sectional study included 82 women (21±2 years) classified according to body fat percentage. Dysfunctional eating patterns were measured with the Spanish version of Three-factor eating questionnaire-R18 and perceived stress was measured with the Spanish version of Perceived Stress Scale–10. A validated in-house ELISA was performed to measure IgG ghrelin-reactive autoAbs in its free, total, and immune complexes fractions. Free IgG ghrelin-reactive autoAbs were positively correlated with weight, BMI, body fat percentage, waist, and hip circumference in women with very high body fat percentage. Moreover, in this group we found a negative correlation between ghrelin immune complexes and uncontrolled eating. This exploratory research shows that IgG ghrelin-reactive autoAbs have a potential role in altered body composition parameters and appetite expression, such as uncontrolled eating in women with very high body fat. Further studies are required to clarify the role of IgG autoAbs in the field of eating behavior.
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