Highlights
Mechanistic studies illustrate the effects of PD on systemic inflammation, platelet and endothelial function, and lipoproteins.
Trials of PD treatment have not shown reductions in cardiovascular outcomes therefore a definite causal association is lacking.
The morbidity and impact on quality of life, mutual risk factors and systemic inflammation warrant preventive efforts.
Improved screening, better collaboration, and targeted health policies could greatly improve prevention of PD and its sequelae.
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