Everybody wants to get success in their life but on the cost of their health. Due to that the chances of irrationality of drugs increase in which self-medication is one of the major cause. The basic principle for the rational use of drug is better supply of drugs, better prescribing and lower costs for health care. When the basic principle of rational use of drugs is not fulfill it leads to irrationality which further leads to adverse effects and toxicity. There are number of factors which contributes to irrationality either they are inter-related to each other or they directly have affects and it may cause some effects on health and economic consequences. There is a cycle for rational use of medicine which help the clinician to prescribe the appropriate drug for appropriate disease condition, if each step is followed appropriately the irrationality improves. The concept of "rational use of medicine" can at times be confusing and not easily appreciated by patients, healthcare providers, policy makers, or the public, all of whom needs to collaborate effectively to address this challenge and the policy makers should be need to update with current trends.
No abstract
Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic illness that has alarmingly high rates of infertility and other significant effects on the health of women. This review study highlighted that Insulin appears to damage every part of the hypothalamus-hypophysis-ovary axis, and insulin resistance in ovarian tissue leads to impaired metabolic signalling but intact mitogenic and steroidogenic activity, favouring hyperandrogenemia, which is thought to be the primary cause of the clinical symptoms of PCOS. This review also enumerates and briefly summarize the research methods related to effects of insulin resistance in PCOS, including molecular mechanism of action of insulin and anabolic processes that stimulate cell growth and differentiation; increase protein and fat storage; and the binding between α, β dimers and receptors on cell surface that results in alteration in gene expression, metabolism and growth.
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