Commercially available bioelectronics account for significant percentage of e-waste, especially battery waste, that demand immediate intervention due to rising environmental concerns. Consumers are becoming increasingly aware and cautious of their contribution to carbon footprint on a regular basis. It has become imperative to adopt sustainability in every aspect of production of bioelectronics taking into consideration the growing market for wearable healthcare monitoring system. Green electronics is a relatively new concept gaining tremendous attention within the scientific and industrial community with the ultimate goal of employing organic, biodegradable, and self-sustainable system to replace the conventional inorganic battery-powered electronics. Silk is a green material that has been extensively explored for its use in functional electronics due to its tunable biodegradability and flexibility. Nevertheless, an intriguing property of Silk is its innate piezoelectricity. This review highlights the importance of crystal orientation and structure of Silk Fibroin to display piezoelectric response and documents possible strategies for its enhancement. It also provides insight into the possibility of using piezoelectric Silk as a piezoelectric sensor, actuator, and energy harvester to form self-powered hybrid systems for autonomous bioelectronics [a] A. Veronica, Prof. I-m. Hsing

Neurological disorders in aging society have created the need to understand how the brain works. At present, there are limited engineered “non‐invasive” tools to study and characterize the brain activity. Advancement in neuroscience research is highly focused on the fabrication of implantable neural probes that can effectively integrate with the neural tissue. Challenges associated with the commercially available probes has driven the development of mechanically compliant and non‐invasive neural implants. Engineering the mechanical and electrical performance of these probes is necessary to obtain tremendous sensitivity and selectivity along with chronic functionality. Selection of proper materials and understanding their fundamentals plays an essential role in achieving the desired neural interface. In this review, we have highlighted the recent progress in the utilization of new materials to attain a neural probe with improved flexibility, biocompatibility and signal quality.

Internal ion‐gated organic electrochemical transistor (IGT) demonstrates volume‐dependent transconductance with the unprecedented advantages of high speed and self‐(de)doping capability among ion‐based transistors. The novel characteristics have albeit rendered IGT a promising platform for integrated bioelectronics, its potential in high‐frequency applications has yet been fully harnessed. Moreover, a study from a material's point of view is especially needed for this recently emerged platform as the necessity of maintaining the internal ion reservoir has posed difficulties in processing hydrated poly(3,4‐ethylenedioxythiophene) doped with poly(styrene sulphonate) (PEDOT:PSS) with electronically favorable morphologies. Herein, a comprehensive investigation of the structural and functional properties of ion‐embedded PEDOT:PSS modified by different annealing temperatures is performed and correlated to the IGT performance. A short‐time high‐temperature annealing treatment is found effective in facilitating the formation of compact microstructures without significantly influencing film hydration. The structural improvement enhances the film's conductivity and hole mobility, with the corresponding IGTs exhibiting higher gain, higher conductance, and high cut‐off frequency consistently in a batch. This study also successfully demonstrates the first use of electrochemical transistors like IGTs in high‐frequency applications through proof‐of‐concept experiments simulating fluid estimation in 50 kHz bioimpedance analysis. This work contributes to the development of high‐performance IGTs for extensive biological applications.