Background: Selenium nanoparticles (SeNPs) have the potential to be used for various applications.The green SeNPs (selenium nanoparticles) are formed by simple mixing Withania somnifera (W. somnifera) leaves extract and selenious acid (H2SeO3) solution. Nanoparticles have revolutionized for targeted drug delivery by minimizing the toxicity and side effects that commercially available drugs may have on patients. In this study we have chosen the clove and cumin because it protects from cholesterol, inflammatory damage and it has antioxidant property Aim: The aim of the study is to analyze the antioxidant activity of clove and cumin formulation mediated selenium nanoparticles. Materials & Methods: Cumin and Clove were powdered and stored in an air-sealed container. 1g of cumin and clove formulation was mixed with 100 ml of distilled water and boiled for 15 minutes and the formulation was filtered with Whatmann No.1 filter paper. 30mM sodium selenite was prepared in 50 ml of distilled water. 50 ml of sodium selenite solution and 50 ml of clove and cumin formulation was mixed and kept in a rotary shaker for 48 hours. UV spectroscopy reading based on color change was observed. Results: The antioxidant effect of selenium nanoparticles showed a higher percentage of inhibition at 50µg/ml in DPPH Assay and H2O2 Assay. The clove and cumin extract showed an increased percentage of inhibition with increasing concentration. Conclusion: The clove and cumin formulation mediated selenium nanoparticles acts as potent antioxidant agents. It also has the least side effects compared to commercial drugs.
Aim: To analyse the preliminary phytochemical, antioxidant, anti-cholesterol potential of aqueous extract of Ferula asafoetida. Background: Hyperlipidemia is considered as one of the leading causes behind the occurrence of deadly disorders like diabetes, cardiovascular diseases, atherosclerosis etc. It is characterised by elevated levels of plasma lipids, mainly total cholesterol. Antioxidants are compounds which can inhibit oxidative damage. is the herbaceous plant belonging to the family Umbelliferae. It is used as spice in food and also used as digestive aid. It is used in the treatment of asthma and whooping cough and it also helps to reduce blood pressure. Methods: Aqueous extract of Ferula asafoetida was prepared by hot percolation method. The screening of phytochemical constituents, assessment of in vitro antioxidant activity and anticholesterol activity were done using standard procedures and the data were analysed statistically using one-way analysis of variance (ONE-WAY ANOVA) and the significance was considered at the levels of p<0.05. Results: Ferula asafoetida extract was rich in phytochemicals and possessed potent in vitro antioxidant activity. Anti-cholesterol activity of Ferula asafoetida extract was examined and it was observed that the plant extract exhibited significant anti cholesterol potential in a dose dependent manner with an IC 50 value of 400 µg/ml. Conclusion: The study established the in vitro antioxidant and hypolipidemic potential of aqueous extract of Ferula asafoetida. It is concluded that the extract of Ferula asafoetida possesses potent antioxidant and anticholesterol activity.
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