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Introduction: Research on depression in local patients with end-stage renal disease (ESRD) is sparse. Thus, this study aims to examine the frequency and severity of depression among ESRD patients and relate depression with their coping skills. Methods: A cross-sectional study using universal sampling method was conducted at several dialysis centers in Kuala Lumpur, Selangor and Johor, Malaysia. The Beck Depression Inventory II (BDI-II) and the Brief COPE scale were used to measure depression and coping skill, respectively. Results: The study involved 274 ESRD patients, comprising of 183 hemodialysis and 91 continuous ambulatory peritoneal dialysis patients. The result showed that 21.1% of the patients experienced moderate to severe depression. Several components of coping skill were associated with depression. However, only two components in the Brief COPE (behavioral disengagement and self-blame) were identified as predictors.

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End-stage renal disease (ESRD) a raising global pandemic known to cause psychological dysfunction but not well studied. The purpose of this study was to measure the influence of illness perception and religious coping strategies on patients' health-related quality of life (HRQoL) and to identify direct or indirect predictors of religious coping on illness perception and HRQoL of ESRD patients. This study involved 274 patients with ESRD who were on chronic maintenance dialysis. Test instruments used included Revised Illness Perception Questionnaire (IPQ-R) to measure patients' perception towards the illness, Religious Coping Strategies questionnaire (RCS) to determine patients' nature of religious coping and Short-Form 36 (SF-36) questionnaire to measure their HRQoL. Results showed that almost all components of illness perception and religious coping strategies were significantly correlated with HRQoL in both aspects of physical component summary (PCS) and mental component summary (MCS). In addition, the findings showed religious coping as a mediator between several illness perception components namely timeline, illness coherence, personal control, consequences and cyclical with PCS and MCS. Attention should be given especially to illness perception and positive religious coping variables in any intervention program to improve the HRQoL of ESRD patients.