A number of new 2,6-didisubstituted pyrimidine, pyrazoline, and pyran derivatives were synthesized starting from their chalcone derivative. The synthesized compounds displayed different degrees of antimicrobial activity against Bscillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes).
The novel and effective diastereoselective
synthesis of multifunctionalized
dihydropyridones, including CF3-substituted derivatives,
has been developed on the basis of the piperidine-promoted domino
reaction of carbamoylated enaminones with aldehydes. The products
have been prepared in 38–90% yields and can be easily isolated
by crystallization. Tautomerism, epimerization, and atropisomerism
of dihydropyridones have been studied. The use of the resulting dihydropyridones
in the synthesis of 1,2,6-trisubstituted 4-pyridone-3-carboxamides
has been demonstrated via oxidative aromatization initiated by iodine.
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