Objectives: The aim of this study is to detection of various thyroid diseases in the early stages and their impact on the metabolic state of the body through the estimation of the Midkine by using ELISA method. Methadology: The current study was conducted on 45 patients with thyroid disease was attending in endocrine and diabetic center in the Al-Sadder Teaching Hospital and Al-Hakim General Hospital in AL-Najaf Province, and 45 healthy person, the samples collected during the period from September 2021 to 2`January. Results: The result of hormonal markers shows high significant with p-value = <0.001 in the level of T3 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. On the other hand, this result was high significant with p-value = <0.001 in the level of T4 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. In addition, this result was high significant with p-value = <0.001 in the level of TSH was higher in Hyperthyroidism compared to Hypothyroidism and the control group. The results of biochemical marker of Midkine was higher in Hyperthyroidism and Hypothyroidism (499.6 ± 120.2 and 489.1 ± 108.1 respectively) compared to and the control group (372.9 ± 92.5).
Background: This review deals with a collection of information about a protein marker that is very important and alternates presence in many cases of normal and pathological growth, as it can be observed in high concentrations in the stages of fetal development and can be expressed significantly in many cases and disorders and midkine is considered a diagnostic marker for them as in types of cancers. It has a protein structure of 121 amino acids and its expression is located on the eleventh chromosome and has several functions, especially its expression in nervous tissues during the mid-gestation.
Conclusion: Midkine plays an important role in the inflammatory process in terms of its importance in the infiltration of immune cells into the peripheral organs and targeting midkine may be a viable new therapeutic option for chronic infections, especially infections of the kidneys, joints, nervous system and colon.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.