Obesity is a chronic metabolic disease identified by excessive fat deposition in the body with the highest risk of disordered lipid profile. Obesity and inappropriate lifestyles such as smoking and fake food not only influence blood lipids but also helps heavy metals and mineral be absorbed and adhered to the tissues with minimal disposal, that producing health problems with ages. A total of 49 female students (18-35 years old) included in this study to assess the relationship between body mass index, heavy metal, and minerals in university students. There is a strong correlation between BMI and potassium, where there is a positively weak relation between selected heavy metal and minerals and BMI. The increases in the presence of heavy metal and minerals in the present study not only depended in the BMI but also as a result of the rise in the effluent flow heavy metal from industrial units found in close nearness to rivers, oceans and seas have ended in an expansion in water bodies and seafood, fruits, vegetable crops and the food chain. That will need further investigation.

Obesity has grown leading global health issues owing to its strong association with a high incidence of diseases that including male infertility. Infertility is the disability of a sexually active, non-contracepting couple to achieve pregnancy and reproduce. Congenital factors, acquired urogenital abnormalities, urogenital tract infections, endocrine disturbances, genetic abnormalities, immunological factors, obesity and lifestyle factors are among of infertility causes. Seminal analysis and serum levels of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) thyroid-stimulating hormone (TSH), Triiodothyronine (T3), Thyroxine (T4) as well as biological profile and anthropometric measurements in obese men evaluated before and after six-month weight loss programme as compared with baseline and reference range. There is a significant reduction in weight and high improvement semen, hormonal, biological profile and anthropometric measurements as compared to the reference range. The results may be due to the combination of the weight loss and improved nutrition.

Acacia senegal (AS) gum (Gum Arabic) is a natural emulsifier exudate from the branches and trunk of Acacia trees and it is recognized by the Food and Drug Administration (FDA) agency as a secure dietary fiber. The present research evaluated the systemic oxidative and necroinflammatory stress induced by CCl4 administration and the alleviating effect of AS gum aqueous extract (ASE, 7.5 g/Kg b.w.). The results demonstrated the presence of certain phenolic compounds in ASE, as well as its in vitro potent scavenging ability against ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), NO, and lipid peroxide radicals. Also, the outcomes revealed an improvement in the CCl4-induced liver, lung, brain, and spleen toxicity by reducing the levels of ROS, lipid peroxidation, NO, and the gene expression of NF-κB and its relevant ROS-mediated inflammatory genes. In contrast, the total antioxidant capacity (TAC), as well as the enzymatic and non-enzymatic antioxidants, were significantly upregulated in these organs after the treatment with ASE. These results were confirmed by improving the morphological features of each organ. Therefore, ASE can ameliorate the systemic toxicity caused by CCl4 via regulation of the ROS/NF-κB signaling pathway in the rat organs, which is owed to its phytochemical composition.

The presence of phenobarbital and formaldehyde in drugs, food, and beverages can lead to various health issues, including inflammation, oncogenesis, and neurological distress. Psychological stress leads to mood fluctuations and the onset of skin inflammation. Skin inflammation has a range of causes, including chemicals, heavy metals, infection, immune-related disorders, genetics, and stress. The various treatments for skin inflammation include medical and cosmetic creams, diet changes, and herbal therapy. In this study, we investigated the effects of Avocom-M and pomegranate seed oil extract (PSOE) against phenobarbital- and formaldehyde-induced skin biochemical changes in rats. We analyzed the constituents of PSOE using gas chromatography–mass spectrometry and inductively coupled plasma–mass spectrometry. We also observed biochemical changes in the skin of human volunteers with and without TROSYD and PSOE as a skin cream. We compared the biochemical changes in human volunteers’ skin before treatment and 21 days after the treatment stopped. The outcomes showed an improvement in the rats’ biochemical status, due to PSOE and Avocom-M treatment. The human volunteers treated with TROSYD and PSOE showed substantial amelioration of skin inflammation. PSOE, Avocom-M, and TROSYD produced beneficial effects by reducing the levels of cyclooxygenase-2, lipid peroxidation, tyrosinase, hyaluronidase, elastase, collagenase, and nitric oxide in the animals tested on and in human volunteers.

Background: most diseases are inequality of the antioxidants, pro-oxidants, and failure in resolved inflammation. Diabetes is a metabolic malfunction associated with inflammation and ends with organs failure. Alternative treatments for diabetes include a lifestyle and an anti-inflammatory diet. Method: we investigated the effects of dietary Ajwa dates seeds extract (AJSO) against alloxan monohydrate-induced biochemical changes. We analyzed the phytochemical components of AJSO with gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry. We determined the effects of oral AJSO on biochemical changes caused by alloxan monohydrate in rats. We also observed biochemical changes in human volunteers with or without Ajwa seed as caffeine-free coffee replacements. Results: the results and outcomes confirmed the improvement in the rats’ biochemical analysis due to AJSO constituents. The treatment of AJSO after alloxan monohydrate injection significantly (p ≤ 0.05) decline the studied parameters NO, MDA, Amyloid A, CRP, and glucose concentrations by 47.2%, 34.8%, 55.6%, 47.4%and 60.0%, respectively, compared to treatment only with alloxan monohydrate. The volunteers treated with Ajwa seed as caffeine-free coffee replacements(group2) showed significant amelioration of inflammatory and diabetes markers as compared to the untreated group1. Group 2 showed a significant decrease in the concentration of serum NO (34.7%), MDA (43.9%), amyloid A (79.6%), CRP (60.9%), HbA1c (33.8%), Troponin T (16.4%), serum total cholesterol (14.2 %), TG (28.1%), LDL-C (6.1%), AST 8.8%, and ALT (11.6%) compared to Group1. Conclusion: AJSO had a healthy impact by decreasing the levels of amyloid a, c-reactive protein, lipid peroxidation, nitric oxide, and improving diabetes, lipid and liver profiles in both rats and human volunteers. Further long-term investigation of higher numbers and the different types and sexes is needed in progress to confirm and validate the results.