Background: Antero-superior, Pituitary Gland lies in vicinity of optic chiasm and antero-inferiorly, it is related with posterior wall of sphenoid bone. Pituitary Gland is consisting of three lobes: Anterior, intermediate and posterior and their secretion are regulated by hypothalamus. Aims and Objectives: To identify pituitary adenoma in the patients coming with complain of chronic headache. Materials and Methods: Seven hundred sixty-four patients were included in our study. All the patients with chronic headache with/without decreased vision and visual field defects were included our study. Those patients already diagnosed with any other cause of headache such as uncontrolled blood pressure, tumor or diagnosed case of pituitary adenoma and patient with glaucoma were excluded. Detailed history was taken and ocular examination was done. MRI orbit and brain with contrast was done in all patients. Results: Out of 764 patients, 32 patients were diagnosed as having pituitary adenoma. Macro-adenoma was present in 30 patients and micro-adenoma in 2 patients. On MRI majority of patients had optic chiasm compression with bi-temporal hemianopia. Conclusion: All the patients with chronic headache with/without visual disturbances and visual field defect must be properly examined and investigated as that will help other researchers to diagnose the Pituitary Adenomas.

Objective: To determine the ddiagnostic accuracy of susceptibility weighted magnetic resonance imaging (SW-MRI) for glioblastoma diagnosis by taking biopsy as gold standard. Material and Methods: This cross-sectional study was done at department of Radiology, Jinnah Postgraduate Medical Center (JPMC), Karachi from June to December 2017. Total 114 cases with focal neurological deficit, seizures, stroke and CT scan findings of a mass with irregular thick margins and symptoms of increased intracranial pressure were enrolled. All the study subjects undergone SWI MRI. Brain biopsy was done during the same period of hospitalization. All the data was collected by study proforma and analysis of data was done by SPSS version 26 Results: Total 114 cases were studied and mean age of the cases was 50.64+10.37 years. Males were in majority 60.5% and females were 39.5%. Lesion average size was 4.34 cm. Glioblastoma was diagnosed among 68.4% cases on SW-MRI, while its was diagnosed among 71.1% study subjects by biopsy. SW-MRI showed sensitivity 90.1%, specificity 84.8%, PPV 93.5%, NPV 77.7% and diagnostic accuracy was found 88.59%. Conclusion: The SW-MRI was observed to be the best diagnostic tool for glioblastoma with diagnostic accuracy of 88.59%, sensitivity 90.1% and specificity 84.8%. This diagnostic tool may helpful to indorse the expected diagnosis in clinical practice.

Background: Retained product of conception (RPOC) has been the commonest factor involved in secondary post-partum hemorrhage. Ultrasound is a valuable diagnostic method for the diagnosis of PPH patients and is much more reliable than clinical presentation for the RPOC diagnosis alone. Objective: To determine the diagnostic accuracy of ultrasound in detection of retained products of conception in postpartum period in clinically suspected patients taking histopathology as gold standard.

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