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The aim of this study was to investigate the histological and biochemical changes in liver of rats exposed to cigarette smoke and effects of caffeic acid phenetyl ester (CAPE) on these changes. For this purpose, 21 male Wistar rats were divided into three groups. Animals in Group I were used as control. Rats in Group II were exposed to cigarette smoke and rats in Group III were exposed to cigarette smoke and injected daily with CAPE. At the end of the 60-days experimental period, all rats were killed by decapitation and blood samples were obtained. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin levels and hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px ), malondialdehyde (MDA) contents were determined. Following routine histological procedures, liver tissue specimens were examined under a light microscope. The levels of ALT, AST, total bilirubin, SOD, GSH-Px and MDA were significantly increased in rats exposed to cigarette smoke compared with those of the controls. Light microscopic examination of liver specimens from rats exposed to cigarette smoke revealed mononuclear cell infiltration and that some of the hepatocytes had a hyperchromatic nucleus and enlarged sinusoids. The rats which were treated with CAPE along with cigarettes had partially attenuated histological changes associated with cigarette exposure. In conclusion, the damage inflicted by cigarette in the rat liver can be partially prevented by CAPE administration.

Aim:The aim of this study was to investigate the toxicity of formaldehyde on lung and protective effects of caffeic acid phenethyl ester against these toxic effects.Methods: For this purpose, 21 male Wistar rats were divided into three groups. The rats in Group I comprised the controls, while the rats in Group II were injected with formaldehyde (FA). The rats in Group III received CAPE daily while exposed to formaldehyde. After the treatment, lungs tissues were evaluated by microscopic examination. Results:In the microscopic examination of FA group, fatty and cellular infiltration in the pulmonary interstitium and thickening in the bronchiolar wall were evident. Dilatation and congestion were prominent in the alveolar septal vessels. In FA+CAPE group, dilatation of interalveolar septal vessels was less observed than FA group. Bronchial wall structures are similar with control.Conclusion: It was thought that FA exposure leads to inflammation and injury in lungs. CAPE shows protective and anti inflammatory activity against these adverse effects.