Drug development plays an important role in patient safety and effectiveness. The therapeutic suitability of a new drug depends on the solubility. The solubility of the sparingly soluble drug remains a problem in identifying new active compounds. Solubility plays an important role in achieving optimal drug concentration. Low solubility is not only a concern for the production of formulations, but also an obstacle from the outset when identifying active chemicals for therapeutic purposes. Due to its simplicity in terms of ease of administration and economy, the oral route is the preferred route of drug administration over other routes. Effective aqueous solubility is the first prerequisite for oral medication, since low solubility has poor absorption and bioavailability and unpredictable toxicity of the gastrointestinal mucosa. To avoid these crises, different methodologies are used to improve the solubility and bioavailability of poorly soluble drugs, and hydrotropic solubilization is one of them. Hydrotropic agents have the potential to improve the solubility of water-insoluble drugs. In this review, we try to address hydrotropic solubilization methodologies. Keywords: Hydrotropy, Micelles, Solubility, Formulation.

Aims: Nanoparticles are the colloidal carrier systems for delivery of poorly soluble drugs. Budesonide. (BUD) a corticosteroid practically insoluble in water is used in asthma treatment. The aim of the present research work was to develop and evaluate BUD nanoparticles. Methodology: The prepared formulation was analyzed for % encapsulation efficiency, particle size analysis, zeta potential, polydispersity index (PDI), scanning electron microscopy and transmission electron microscopy. Poloxamer-188 was found in stabilizing BUD nanoparticles. Results: The observed % encapsulation efficiency of the optimized batch was (82.95) %, particle size was 271.8 nm with PDI 0.456. Solvent injection method was successfully implemented to developed BUD nanoparticles poloxamer-188. Sonication time and amplitude played an important role in governing the particle size. Conclusion: It can be inferred from the study that nanoparticles are a potential drug delivery method for poorly water-soluble drug delivery which can not only get impacted by formulation variables but also by process variables.

Generally, it is said that the lymph node plays very important role in the cancer immunotherapy. So, delivering immunomodulating compounds to lymph node can be useful strategy for cancer immunotherapy. In case of this lymph node drug delivery system, lipid nanoparticles are widely used. High amount of drugs, nucleic acids and various other compounds can easily load in lipid nanoparticle, and they are easy to be manufacture on industrial scale also. In this review, we have focused on the potential of lipid nanoparticle technology to aim lymph nodes. However, there are many factors that control the delivery of drugs to lymphatics. Before the lymphatic detection, lipid nanoformulations are necessary to go through interstitial hindrance which alters delivery of them. So, the distribution and detection of lipid nanoformulations by means of lymphatic system depend on charge present on nanoparticles, hydrophobicity, particle size and molecular weight, form & type of lipid and emulsifier concentrations are as well significant factors disturbing the delivery of drugs in the lymphatic system.

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Wearable devices (WDs) and mHealth (Mobile Health) give you the healthcare services, overcoming geographical, temporal or even organizational obstacles. Wearable technologies will have non-encroaching and sovereign devices that collect save and examine physiological information that will certainly help to improve patient health. It has been used so far for fitness purposes. But with increasing demand by patients and health care workers, wearable devices have also been developed to monitor patient health-related issues. It collects and analyses data. In some scenarios makes a sensible decision and provide a suitable response to the users. Now a day, mobile applications have also proven effective in the field of medicine with the motto of giving personalized treatment to disease control. Advanced technology in wearable gadgets has become a great aspect of our day-to day life in addition to the health care industry. A global pandemic that the world is facing in the form of COVID19 has come up with the importance of clinical research and technologies which help to tackle COVID 19 infection worldwide in an exceptional manner. While expected results have been found on effective use of wearable devices and mHealth systems to study the structure of COVID 19 and upcoming infectious ailment. The objective of this review is to test permitting technologies and structures with diverse utility to deal with the COVID 19 disaster. This review acknowledges the researchers of the wearable devices and mHealth systems which proved their significance in the present pandemic. Also, this review explains the exceptional tracking devices, which include heart rate, temperature and oxygen monitoring that, are used to diagnose COVID 19 patients.

Wound healing has always been an important issue that needs to be addressed, especially where second-and third-degree burns are considered. These types of burns extend to the dermis in second-degree burns and the tissues in third-degree burns and this process is extremely slow. Hypertrophic scarring and infection which are caused due to decreased immunity are some of the obstacles that need to be tackled. Recent studies show that fish collagen is useful in preventing infections due to its natural antimicrobial properties. Increased cellular respiration, exudate removal and retention of moisture are a few events that promote wound healing and these are aided by electrospun nanofibrous mats. Combining the properties of collagen into the nanofibrous mats in order to facilitate wound healing can potentially serve as an alternative to the current wound healing therapies. This article covers the various types of collagen that can be used with a focus on the synthetic polymeric blending into the collagen structures and its electrospinning process.

Dabigatran Etexilate Mesylate (DEM), a salt of prodrug dabigatran etexilate, is a potent, oral, reversible and direct thrombin inhibitor with low oral bioavailability. The present research investigation focused on the formulation of immediate release (IR) tablets of DEM cocrystals and evaluation of In vivo anticoagulant activity. The results of the study showed that the formulated IR tablets of DEM showed improved efficacy in comparison with the plain drug by enhancing the pre-compression parameters such as bulk density, tap density, Carr's index, angle of repose and Hausner's ratio and post-compression parameters like thickness and weight variation, hardness and friability, In vitro dissolution parameters. The improved efficacy was confirmed by improvement in the pharmacodynamic parameters such as cutaneous bleeding time and clotting time indicative of enhanced bioavailability of dabigatran. Thus, it can be concluded that the IR tablets of dabigatran cocrystals can be proven to be more effective in producing the anticoagulant effect in clinical practice as compared to the plain drug resulting in more patient compliance.

Microemulsions (ME) is a system that combines water, oil, and an emulsifier / surfactant which is a form of volatile liquid, homogeneous and kinetically stable. Microemulsion is an attractive drug delivery system for topical administration. Due to its solubility, mild skin irritation, and watery swelling are used in the Topical Drug Delivery System (TDDS). By improving the quality of skin texture, it provides a level of penetration. The function of skin balance is to limit the penetration of bacteria, viruses, and other environmental factors. With standard drugs, skin penetration may take time and have not been able to provide immediate action. So, in this case, we used the Microemulsion-based Topical Drug Delivery system. Microemulsion increases solubility, protects the drug from environmental factors and improves drug bioavailability. MEs provide high penetration and the ability to penetrate into the skin. Because of this, the immediate action of the drug can occur in the infected area. Due to the presence of a hydrophilic and lipophilic environment, it provides outstanding biocompatibility. There are several test frames used to maintain stability, microemulsion kinetics.