Introduction:
Quinoxalines show diversified applications in the field of medicinal chemistry.
Materials and Methods:
Therefore, we have designed highly efficient, environmentally benign and one-pot
protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and
1,2-phenylenediamine under ultrasound irradiation in glycerol-water.
Results and Discussion:
We observed that, although the reaction efficiently completed in all of these solvents,
the use of glycerol-water with different ratio give consistently higher yields (89–94%) and decrease reaction times.
Conclusion:
The main advantages of this protocol are green method; avoid use of toxic catalyst and volatile
organic medium and product obtained with excellent yield.
A green and environmentally benign protocol is developed for the synthesis of Schiff bases of sulphur containing compound by irradiating thiazole and pyrazole aldehyde in glycerol under microwave irradiation at 70 ºC with trimethylsilyl chloride (TMSCl) as a catalyst. The method has advantages such as excellent yield, use of green solvent, easy work-up and most important the reaction completed within 2.5 min by using TMSCl catalyst. The TMSCl is an acidic catalyst, which enhances the yield of product, reaction time (with microwave, with reflux at 75 ºC and with stirring at room temperature) which can be easily removed from reaction mask.
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